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rdf:type |
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lifeskim:mentions |
umls-concept:C0005595,
umls-concept:C0029016,
umls-concept:C0033634,
umls-concept:C0033684,
umls-concept:C0035696,
umls-concept:C0205250,
umls-concept:C0439849,
umls-concept:C0443199,
umls-concept:C0445223,
umls-concept:C0851285,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C2587213
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pubmed:issue |
4
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pubmed:dateCreated |
1992-6-8
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pubmed:databankReference |
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pubmed:abstractText |
An RNA identified by differential cDNA cloning (HAT-2) is highly enriched in canary forebrain in areas associated with the control of complex learned behaviors and higher perceptual processes. The nucleotide sequence predicts a protein that is 96% identical to the product of the n-chimaerin gene isolated from human brain and contains two identifiable domains suggesting a novel role in signal transduction processes. One domain is similar to the sequence in protein kinase C which mediates diacylglycerol binding and regulation. The second domain is similar to a portion of BCR, a GTPase-activating protein encoded by the breakpoint cluster region gene. In male canaries examined during the song season, HAT-2 RNA shows variable expression within the song control circuit, and is notably less abundant in the three nuclei which concentrate androgens (HVC, RA and L-MAN). A fundamental function in the vertebrate forebrain and a possible role in the regulation of neural plasticity are suggested by the conserved structure and pattern of expression of this gene in the brain.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/GTPase-Activating Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorus Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Poly A,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcr,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0169-328X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:geneSymbol |
HAT-2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
323-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1374499-Amino Acid Sequence,
pubmed-meshheading:1374499-Animals,
pubmed-meshheading:1374499-Autoradiography,
pubmed-meshheading:1374499-Base Sequence,
pubmed-meshheading:1374499-Blotting, Northern,
pubmed-meshheading:1374499-Brain,
pubmed-meshheading:1374499-Canaries,
pubmed-meshheading:1374499-Cloning, Molecular,
pubmed-meshheading:1374499-DNA,
pubmed-meshheading:1374499-GTPase-Activating Proteins,
pubmed-meshheading:1374499-Male,
pubmed-meshheading:1374499-Molecular Sequence Data,
pubmed-meshheading:1374499-Neurons,
pubmed-meshheading:1374499-Oncogene Proteins,
pubmed-meshheading:1374499-Oncogenes,
pubmed-meshheading:1374499-Phosphorus Radioisotopes,
pubmed-meshheading:1374499-Poly A,
pubmed-meshheading:1374499-Protein Kinase C,
pubmed-meshheading:1374499-Protein-Tyrosine Kinases,
pubmed-meshheading:1374499-Proteins,
pubmed-meshheading:1374499-Proto-Oncogene Proteins,
pubmed-meshheading:1374499-Proto-Oncogene Proteins c-bcr,
pubmed-meshheading:1374499-RNA,
pubmed-meshheading:1374499-RNA, Messenger,
pubmed-meshheading:1374499-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1374499-Vocalization, Animal
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pubmed:year |
1992
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pubmed:articleTitle |
Differential regulation in the avian song control circuit of an mRNA predicting a highly conserved protein related to protein kinase C and the bcr oncogene.
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pubmed:affiliation |
Laboratory of Animal Behavior, Rockefeller University, New York, NY 10021.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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