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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1992-6-2
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pubmed:abstractText |
A randomised placebo-controlled trial was conducted to investigate the effect of iloprost, a stable prostacyclin mimetic, on peripheral resistance during femoro-distal bypass. Patients undergoing femoro-distal long saphenous vein bypass for critical ischaemia received 3000 ng of iloprost or placebo infused into the graft via an unligated side branch over 2 min. Graft blood flow and peripheral resistance were measured for 20 min, using an operative Doppler flowmeter (OpDop 130, SciMed, U.K.) and a pressure transducer to record graft pressure. Postoperatively, graft blood flow was assessed by daily duplex ultrasound for 7 days. Iloprost produced an immediate drop in peripheral resistance in all cases (n = 18) by a mean (range) of 40% (4-80%) compared with controls (n = 15) in whom there was a 5.3% (-8 to +36%) increase in resistance (p less than 0.01, Wilcoxon test). Decreased peripheral resistance in iloprost-treated patients persisted to 20 min. The largest decreases in peripheral resistance occurred in patients with the highest initial resistances (r = 0.56, p less than 0.02). Graft flow during the same period increased by 52% (-7 to 294%) compared with controls in whom there was a 6% (-17 to 26%) increase in flow, (p less than 0.01). Flow remained elevated by 53% over baseline values at 1 week post-infusion in the iloprost-treated group but this did not achieve statistical significance compared to controls in whom flow also increased by 13%. Iloprost produces an immediate decrease in peripheral resistance associated with a prolonged increase in graft blood flow. This may reduce graft failure in the early postoperative period.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0950-821X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
194-8
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:1374040-Aged,
pubmed-meshheading:1374040-Anastomosis, Surgical,
pubmed-meshheading:1374040-Drug Administration Schedule,
pubmed-meshheading:1374040-Female,
pubmed-meshheading:1374040-Femoral Artery,
pubmed-meshheading:1374040-Humans,
pubmed-meshheading:1374040-Iloprost,
pubmed-meshheading:1374040-Intraoperative Period,
pubmed-meshheading:1374040-Ischemia,
pubmed-meshheading:1374040-Leg,
pubmed-meshheading:1374040-Male,
pubmed-meshheading:1374040-Middle Aged,
pubmed-meshheading:1374040-Vascular Resistance
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pubmed:year |
1992
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pubmed:articleTitle |
Iloprost reduces peripheral resistance during femoro-distal reconstruction.
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pubmed:affiliation |
University Department of Vascular Surgery, Queen Elizabeth Hospital, Edgbaston, Birmingham, U.K.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|