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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5056
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pubmed:dateCreated |
1992-5-22
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pubmed:databankReference |
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pubmed:abstractText |
The mammalian splicing factor SC35 is required for the first step in the splicing reaction and for spliceosome assembly. The cloning and characterization of a complementary DNA encoding this protein revealed that it is a member of a family of splicing factors that includes mammalian SF2/ASF. This family of proteins is characterized by the presence of a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal serine-arginine-rich (SR) domain. A search of the DNA sequence database revealed that the thymus-specific exon (ET) of the c-myb proto-oncogene is encoded on the antisense strand of the SC35 gene.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
256
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
535-8
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pubmed:dateRevised |
2011-9-27
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pubmed:meshHeading |
pubmed-meshheading:1373910-Amino Acid Sequence,
pubmed-meshheading:1373910-Animals,
pubmed-meshheading:1373910-Baculoviridae,
pubmed-meshheading:1373910-Base Sequence,
pubmed-meshheading:1373910-Binding Sites,
pubmed-meshheading:1373910-Blotting, Northern,
pubmed-meshheading:1373910-Cell Line,
pubmed-meshheading:1373910-Cloning, Molecular,
pubmed-meshheading:1373910-Codon,
pubmed-meshheading:1373910-DNA,
pubmed-meshheading:1373910-Exons,
pubmed-meshheading:1373910-Humans,
pubmed-meshheading:1373910-Molecular Sequence Data,
pubmed-meshheading:1373910-Nuclear Proteins,
pubmed-meshheading:1373910-Proteins,
pubmed-meshheading:1373910-Proto-Oncogene Proteins,
pubmed-meshheading:1373910-Proto-Oncogene Proteins c-myb,
pubmed-meshheading:1373910-RNA,
pubmed-meshheading:1373910-RNA Splicing,
pubmed-meshheading:1373910-Ribonucleoproteins,
pubmed-meshheading:1373910-Sequence Homology, Nucleic Acid,
pubmed-meshheading:1373910-Transfection
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pubmed:year |
1992
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pubmed:articleTitle |
Isolation of a complementary DNA that encodes the mammalian splicing factor SC35.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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