Linked Life Data

1373580

Source:http://linkedlifedata.com/resource/pubmed/id/1373580

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1992-5-21
pubmed:abstractText
T-cell-rich B-cell lymphomas (TCRBCLs) are recently described, unusual non-Hodgkin's lymphomas that have a diffuse morphology, a predominance of reactive T-cells, and a minority of neoplastic B-cells. The clinical and pathological features of 19 TCRBCLs, all of which demonstrated B-cell clonality, are presented. These lymphomas generally affected older patients by widespread disease and usually were nodal in origin. Treatment varied, but continuous complete remissions (eight patients) were achieved only in those receiving chemotherapy directed at intermediate-grade lymphomas. Although morphologically heterogeneous, all cases resembled peripheral T-cell lymphomas (PTCLs); several TCRBCLs also contained Reed-Sternberg-like cells. Flow cytometry or frozen-section immunoperoxidase failed to detect monotypic immunoglobulin (Ig) in eight of eight cases tested. In contrast, paraffin immunoperoxidase was very useful diagnostically, showing large L26 (CD20-associated) positive cells scattered singly or in small clusters among numerous small T-cells (UCHL1[CD45RO] positive) in all cases. Monotypic cytoplasmic Ig was present in 16 of 19 cases, one of which exhibited plasmacytic differentiation. Southern blot analysis demonstrated relatively faint Ig JH and/or JK bands, indicating a small monoclonal B-cell population in nine of 11 cases, one of which also showed a bcl-2 rearrangement. No T-cell receptor gene rearrangements were observed. These results showed that TCRBCLs may be easily confused with PTCLs or occasionally confused with Hodgkin's disease. TCRBCLs are probably heterogeneous biologically; some cases are of follicular center cell origin. These lymphomas respond to chemotherapy directed at intermediate-grade lymphomas, apparently have a better prognosis than PTCLs, and seem to represent morphological variants of different types of large B-cell lymphomas.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0147-5185
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
351-63
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:1373580-Adolescent, pubmed-meshheading:1373580-Adult, pubmed-meshheading:1373580-Aged, pubmed-meshheading:1373580-Aged, 80 and over, pubmed-meshheading:1373580-Antigens, CD, pubmed-meshheading:1373580-Antigens, CD20, pubmed-meshheading:1373580-Antigens, CD45, pubmed-meshheading:1373580-Antigens, Differentiation, B-Lymphocyte, pubmed-meshheading:1373580-Blotting, Southern, pubmed-meshheading:1373580-DNA, Neoplasm, pubmed-meshheading:1373580-Diagnosis, Differential, pubmed-meshheading:1373580-Female, pubmed-meshheading:1373580-Flow Cytometry, pubmed-meshheading:1373580-Genotype, pubmed-meshheading:1373580-Histocompatibility Antigens, pubmed-meshheading:1373580-Hodgkin Disease, pubmed-meshheading:1373580-Humans, pubmed-meshheading:1373580-Immunoenzyme Techniques, pubmed-meshheading:1373580-Immunophenotyping, pubmed-meshheading:1373580-Lymphoma, B-Cell, pubmed-meshheading:1373580-Lymphoma, T-Cell, Peripheral, pubmed-meshheading:1373580-Male, pubmed-meshheading:1373580-Middle Aged, pubmed-meshheading:1373580-T-Lymphocytes
pubmed:year
1992
pubmed:articleTitle
T-cell-rich B-cell lymphomas. A clinicopathologic study of 19 cases.
pubmed:affiliation
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't