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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1992-5-15
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pubmed:abstractText |
Substantial proportions of resting B cells constitutively express low levels of IL-2 receptor (IL-2R) alpha and/or beta chains. The expression of these chains is differentially regulated by anti-IgM and IL-2/IL-4. The anti-IgM induces IL-2R alpha chain expression, whereas each of the two cytokines induces IL-2R beta chain expression in a dose-dependent manner. Moreover, IL-2 induces the growth of B cells, when the cells were pretreated with IL-2 or IL-4 for 24 h. The magnitude of this IL-2-driven B-cell growth depends upon the level of IL-2R beta chain expression. Costimulation of the B cells with IL-2 and anti-IgM shifts the dose-response curve, and the cells proliferate at an IL-2 concentration as low as 40 pM. These results indicate that the levels of anti-IgM-induced IL-2R alpha chain and IL-2-induced IL-2R beta chain determine the sensitivity of the cells to IL-2.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-1692080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-1918958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-2117031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-2155425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-2295790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-2492678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-2584707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-2590941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-2785715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-2786996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3008337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3040856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3095922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3096574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3098894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3099289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3106825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3108674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3110352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3116668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3131876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3297106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3921620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-3925347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-6090574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-6090948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-6090949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-6206144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-6412230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-6434689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-6439814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-6601148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-6795304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373502-6977612
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3551-5
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1373502-Animals,
pubmed-meshheading:1373502-B-Lymphocytes,
pubmed-meshheading:1373502-Cells, Cultured,
pubmed-meshheading:1373502-DNA Probes,
pubmed-meshheading:1373502-DNA Replication,
pubmed-meshheading:1373502-Female,
pubmed-meshheading:1373502-Fluorescent Antibody Technique,
pubmed-meshheading:1373502-Gene Expression,
pubmed-meshheading:1373502-Immunoglobulin M,
pubmed-meshheading:1373502-Interleukin-2,
pubmed-meshheading:1373502-Interleukin-4,
pubmed-meshheading:1373502-Kinetics,
pubmed-meshheading:1373502-Lymphocyte Activation,
pubmed-meshheading:1373502-Macromolecular Substances,
pubmed-meshheading:1373502-Mice,
pubmed-meshheading:1373502-Mice, Inbred BALB C,
pubmed-meshheading:1373502-RNA,
pubmed-meshheading:1373502-RNA, Messenger,
pubmed-meshheading:1373502-Receptors, Interleukin-2,
pubmed-meshheading:1373502-Time Factors
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pubmed:year |
1992
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pubmed:articleTitle |
Role and regulation of interleukin (IL)-2 receptor alpha and beta chains in IL-2-driven B-cell growth.
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pubmed:affiliation |
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
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