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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1992-5-15
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pubmed:abstractText |
The endogenous inhibitory role of the neuropeptide galanin in pain transmission and spinal cord excitability was demonstrated by the use of a high-affinity galanin receptor antagonist, M-35 [galanin-(1-13)-bradykinin-(2-9)-amide]. M-35, which displaced 125I-labeled galanin from membranes of rat dorsal spinal cord with an IC50 of 0.3 nM, dose-dependently antagonized the effect of intrathecal galanin on the flexor reflex. M-35 potentiated the facilitation of the flexor reflex by conditioning stimulation of cutaneous unmyelinated afferents in rats with intact nerves and the potentiating effect of M-35 on the conditioning-stimulation-induced reflex facilitation of the cutaneous unmyelinated afferents was strongly enhanced after axotomy. These results demonstrate that endogenous galanin plays a tonic inhibitory role in the mediation of spinal cord excitability, and it is particularly noteworthy that this function of galanin is remarkably enhanced after peripheral nerve section.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-1376272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-1700843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-1707368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-1711194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-1711400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-1720225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-1720557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-221070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2412667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2417156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2424949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2430242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2430570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2450311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2465669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2468668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2469577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2470586,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2471574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2472969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2477525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2479648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2484006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2484726,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2574064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-2896357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-3708358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-4827166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-6197320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-6208507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373497-6520794
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3334-7
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1373497-Animals,
pubmed-meshheading:1373497-Bradykinin,
pubmed-meshheading:1373497-Cell Membrane,
pubmed-meshheading:1373497-Decerebrate State,
pubmed-meshheading:1373497-Female,
pubmed-meshheading:1373497-Galanin,
pubmed-meshheading:1373497-Injections, Spinal,
pubmed-meshheading:1373497-Male,
pubmed-meshheading:1373497-Neuropeptides,
pubmed-meshheading:1373497-Pain,
pubmed-meshheading:1373497-Peptide Fragments,
pubmed-meshheading:1373497-Peptides,
pubmed-meshheading:1373497-Rats,
pubmed-meshheading:1373497-Rats, Inbred Strains,
pubmed-meshheading:1373497-Receptors, Galanin,
pubmed-meshheading:1373497-Receptors, Gastrointestinal Hormone,
pubmed-meshheading:1373497-Reflex,
pubmed-meshheading:1373497-Sciatic Nerve,
pubmed-meshheading:1373497-Spinal Cord
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pubmed:year |
1992
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pubmed:articleTitle |
Galanin-mediated control of pain: enhanced role after nerve injury.
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pubmed:affiliation |
Department of Clinical Physiology, Karolinska Institute, Huddinge University Hospital, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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