| pubmed-article:1373354 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1373354 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:1373354 | lifeskim:mentions | umls-concept:C0079720 | lld:lifeskim |
| pubmed-article:1373354 | lifeskim:mentions | umls-concept:C0026272 | lld:lifeskim |
| pubmed-article:1373354 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:1373354 | lifeskim:mentions | umls-concept:C1304884 | lld:lifeskim |
| pubmed-article:1373354 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1373354 | pubmed:dateCreated | 1992-5-15 | lld:pubmed |
| pubmed-article:1373354 | pubmed:abstractText | CD4+ (helper/inducer) T lymphocyte subsets were studied in the peripheral blood from patients with mixed connective tissue disease (MCTD) by double-labelling immunofluorescence. The proportion of CD4+CD45RA+ cells was higher (P less than 0.01) when compared with controls, whereas CD4+CD29+ cells were markedly diminished (P less than 0.001). CD4+CD29+ cells were lower than in patients with progressive systemic sclerosis who were studied in parallel. Upon stimulation with phytohaemagglutinin, CD4+ cells from MCTD patients showed a strong reactivity to acquire the CD29+ phenotype. Expression of high levels of CD29 and other adhesion molecules might lead to facilitated localization of CD4+ cells to inflamed tissue. It is suggested that an increased responsiveness of CD4+ cells to activation signals in vivo and accumulation of CD4+CD29+ cells at tissue sites could result in depletion of this cell subset in the peripheral blood of patients with MCTD. | lld:pubmed |
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| pubmed-article:1373354 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1373354 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1373354 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1373354 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:1373354 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:1373354 | pubmed:author | pubmed-author:BeckerHH | lld:pubmed |
| pubmed-article:1373354 | pubmed:author | pubmed-author:FederlinKK | lld:pubmed |
| pubmed-article:1373354 | pubmed:author | pubmed-author:LangrockAA | lld:pubmed |
| pubmed-article:1373354 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1373354 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:1373354 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1373354 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1373354 | pubmed:pagination | 91-5 | lld:pubmed |
| pubmed-article:1373354 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1373354 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1373354 | pubmed:articleTitle | Imbalance of CD4+ lymphocyte subsets in patients with mixed connective tissue disease. | lld:pubmed |
| pubmed-article:1373354 | pubmed:affiliation | III. Medizinische Klinik und Poliklinik, Universität Giessen, Germany. | lld:pubmed |
| pubmed-article:1373354 | pubmed:publicationType | Journal Article | lld:pubmed |
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