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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-5-15
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pubmed:abstractText |
CD4+ (helper/inducer) T lymphocyte subsets were studied in the peripheral blood from patients with mixed connective tissue disease (MCTD) by double-labelling immunofluorescence. The proportion of CD4+CD45RA+ cells was higher (P less than 0.01) when compared with controls, whereas CD4+CD29+ cells were markedly diminished (P less than 0.001). CD4+CD29+ cells were lower than in patients with progressive systemic sclerosis who were studied in parallel. Upon stimulation with phytohaemagglutinin, CD4+ cells from MCTD patients showed a strong reactivity to acquire the CD29+ phenotype. Expression of high levels of CD29 and other adhesion molecules might lead to facilitated localization of CD4+ cells to inflamed tissue. It is suggested that an increased responsiveness of CD4+ cells to activation signals in vivo and accumulation of CD4+CD29+ cells at tissue sites could result in depletion of this cell subset in the peripheral blood of patients with MCTD.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-1671837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-1696188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-1829991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-1831615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-1878134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-1968077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2083165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2116249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2138008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2144907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2397608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2456868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2477250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2642587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2784042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2894392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2950134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2958011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2959423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2960772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2964476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2965180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-2972769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-3102135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-3155770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-3157750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-3258747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-4621694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-6375682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-6421522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-6444819,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-6603315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-6749996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-6967141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-7362686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1373354-7378088
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
91-5
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1373354-Adult,
pubmed-meshheading:1373354-Antigens, CD,
pubmed-meshheading:1373354-Antigens, CD29,
pubmed-meshheading:1373354-Antigens, CD4,
pubmed-meshheading:1373354-Antigens, CD45,
pubmed-meshheading:1373354-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1373354-Female,
pubmed-meshheading:1373354-Histocompatibility Antigens,
pubmed-meshheading:1373354-Humans,
pubmed-meshheading:1373354-Male,
pubmed-meshheading:1373354-Middle Aged,
pubmed-meshheading:1373354-Mixed Connective Tissue Disease,
pubmed-meshheading:1373354-Scleroderma, Systemic,
pubmed-meshheading:1373354-T-Lymphocyte Subsets
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pubmed:year |
1992
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pubmed:articleTitle |
Imbalance of CD4+ lymphocyte subsets in patients with mixed connective tissue disease.
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pubmed:affiliation |
III. Medizinische Klinik und Poliklinik, Universität Giessen, Germany.
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pubmed:publicationType |
Journal Article
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