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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1992-5-14
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pubmed:abstractText |
We studied 23 cases of angioimmunoblastic lymphadenopathy (AILD) and AILD-like lymphoma for evidence of Epstein-Barr virus (EBV) using the polymerase chain reaction (PCR) and in situ hybridization studies. EBV nucleic acid sequences were found by either PCR or in situ hybridization in 96% of the cases. There was a wide range in the number of EBV-positive cells among the different cases as detected by in situ hybridization. The EBV-positive cells most often possessed nuclei of intermediate to large size. Double-labeling immunohistochemistry/in situ hybridization studies demonstrated that most of the EBV-positive cells expressed the B-lineage antigen CD20 (as detected by L26), with a minority of the EBV-positive cells stained for the T-lineage associated antigen, CD43 (as detected by Leu 22). The abnormally high amounts of EBV found in AILD and AILD-like lymphoma may be a reflection of decreased immunocompetence in these patients. The presence of EBV-positive B cells may explain the presence of B-cell clones found by others as well as the paradoxical occurrence of B-cell lymphoma in a primary T-cell lymphoproliferative disorder.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD20,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD43,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/UN1 sialoglycoprotein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
79
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1789-95
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pubmed:dateRevised |
2011-9-7
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pubmed:meshHeading |
pubmed-meshheading:1373088-Adult,
pubmed-meshheading:1373088-Aged,
pubmed-meshheading:1373088-Antigens, CD,
pubmed-meshheading:1373088-Antigens, CD20,
pubmed-meshheading:1373088-Antigens, CD43,
pubmed-meshheading:1373088-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:1373088-DNA, Viral,
pubmed-meshheading:1373088-Female,
pubmed-meshheading:1373088-Genes, Viral,
pubmed-meshheading:1373088-Herpesvirus 4, Human,
pubmed-meshheading:1373088-Humans,
pubmed-meshheading:1373088-Immunoblastic Lymphadenopathy,
pubmed-meshheading:1373088-Immunohistochemistry,
pubmed-meshheading:1373088-Lymph Nodes,
pubmed-meshheading:1373088-Lymphoma,
pubmed-meshheading:1373088-Male,
pubmed-meshheading:1373088-Middle Aged,
pubmed-meshheading:1373088-Nucleic Acid Hybridization,
pubmed-meshheading:1373088-Polymerase Chain Reaction,
pubmed-meshheading:1373088-RNA, Viral,
pubmed-meshheading:1373088-Sialoglycoproteins
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pubmed:year |
1992
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pubmed:articleTitle |
Detection and localization of Epstein-Barr viral genomes in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma.
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pubmed:affiliation |
Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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