rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1976-4-1
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pubmed:abstractText |
The enhancement of ergot alkaloid production by tryptophan and its analogues in both normal and high-phosphate cultures is more directly related to increased dimethylallyltryptophan (DMAT) synthetase activity rather than to a lack of regulation of the tryptophan biosynthetic enzymes. Thiotryptophan [beta-(1-benzo-thien-3-yl)-alanine] is rather ineffective in the end product regulation of tryptophan biosynthesis, whereas tryptophan and 5-methyltryptophan are potent effectors. The presence of increased levels of DMAT synthetase in ergot cultures supplemented with tryptophan or thiotryptophan, and to a lesser extent with 5-methyltryptophan, suggests that the induction effect involves de novo synthesis of the enzyme. Thiotryptophan and tryptophan but not 5-methyltryptophan can overcome the block of alkaloid synthesis by inorganic phosphate. The results with thiotryptophan indicate that the phosphate effect cannot be explained merely on the basis of a block of tryptophan synthesis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-13654249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-14249036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-4567790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-4738311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-4840428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-4965952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-5086659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-5160408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-5322804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-5423282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-5446431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372-5497438
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
125
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
158-65
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1976
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pubmed:articleTitle |
Physiological study of ergot: induction of alkaloid synthesis by tryptophan at the enzymatic level.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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