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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1992-4-17
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pubmed:databankReference |
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pubmed:abstractText |
We report the complete coding sequence of a cDNA, designated CYL2, derived from a murine erythroleukemia cell library. CYL2 is considered to encode a D-type cyclin because (i) there is cross hybridization with CYL1 (a murine homolog of human cyclin D1) and the encoded protein has 64% amino acid sequence identity with CYL1 and (ii) murine erythroleukemia cell-derived CYL2 contains an amino acid sequence identical to that previously reported for the C-terminal portion of a partially sequenced CYL2. Transcripts of murine erythroleukemia cell CYL2 undergo alternative polyadenylylation like that of human cyclin D1. A major 6.5-kilobase CYL2 transcript changes its expression during the cell cycle with a broad peak through G1 and S phases and a decrease in G2/M phases. The present findings suggest that CYL2 plays a role in the G1 to S phase progression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-177980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-1826542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-1827756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-1827757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-1828291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-1833062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-1833066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-1833068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-1846030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-1967822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2138713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2142620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2143810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2143983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2147521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2147872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2149647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2173140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2192266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2569741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2570636,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2574633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2576632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2683075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2683077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2876518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-2907481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-291983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-3062366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-3162770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-3287181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-3289755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-3516412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-3553962,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-3889921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-6134587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-6198242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-7045699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1372445-7254352
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2444-7
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1372445-Amino Acid Sequence,
pubmed-meshheading:1372445-Animals,
pubmed-meshheading:1372445-Base Sequence,
pubmed-meshheading:1372445-Blotting, Northern,
pubmed-meshheading:1372445-Cell Cycle,
pubmed-meshheading:1372445-Cell Line,
pubmed-meshheading:1372445-Cell Nucleus,
pubmed-meshheading:1372445-Cloning, Molecular,
pubmed-meshheading:1372445-Cyclins,
pubmed-meshheading:1372445-DNA, Neoplasm,
pubmed-meshheading:1372445-Gene Library,
pubmed-meshheading:1372445-Humans,
pubmed-meshheading:1372445-Leukemia, Erythroblastic, Acute,
pubmed-meshheading:1372445-Mice,
pubmed-meshheading:1372445-Molecular Sequence Data,
pubmed-meshheading:1372445-Poly A,
pubmed-meshheading:1372445-RNA,
pubmed-meshheading:1372445-RNA, Messenger,
pubmed-meshheading:1372445-Sequence Homology, Nucleic Acid
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pubmed:year |
1992
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pubmed:articleTitle |
Cloning of a D-type cyclin from murine erythroleukemia cells.
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pubmed:affiliation |
DeWitt Wallace Research Laboratory, Memorial Sloan-Kettering Cancer Center, New York, NY.
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pubmed:publicationType |
Journal Article,
Comparative Study
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