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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-4-21
|
| pubmed:abstractText |
Multiple immunological parameters, including total lymphocyte count, lymphocyte subpopulations (CD2+, CD19+, CD3+, CD4+ and CD8+), phytohemagglutinin (PHA) response, and natural killer (NK) activity, were measured in 66 patients with previously untreated esophageal carcinoma. The influence of preoperative treatment and/or surgical operation on the immune function were evaluated in 40 patients. The PHA response and NK activity of the patients with esophageal carcinoma were 229 +/- 103 S.I.% and 18.5 +/- 11.9% lysis, respectively, and were significantly depressed as compared with the control. The CD4+/CD8+ ratio, PHA response, and NK activity in stage IV were also significantly depressed compared to that in stages I-III. Preoperative treatment induced significant reductions in the total lymphocyte count (1,994 +/- 644 to 670 +/- 274/mm3), PHA response (219 +/- 77 to 159 +/- 59 S.I.%), and NK activity (19.7 +/- 13.2 to 11.1 +/- 10.3% lysis) as well as a significant gradual decrease in the CD4+/CD8+ ratio (2.09 +/- 1.42 to 0.69 +/- 0.48), while the surgical operation significantly influenced only the total lymphocyte count. This study demonstrates that preoperative treatment induces a more pronounced influence on the immune function than surgical operation alone, in patients with esophageal carcinoma in which the immune function is disturbed prior to these treatments.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-4790
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
176-81
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1372377-Adult,
pubmed-meshheading:1372377-Aged,
pubmed-meshheading:1372377-Aged, 80 and over,
pubmed-meshheading:1372377-Antigens, CD,
pubmed-meshheading:1372377-Bleomycin,
pubmed-meshheading:1372377-Combined Modality Therapy,
pubmed-meshheading:1372377-Esophageal Neoplasms,
pubmed-meshheading:1372377-Female,
pubmed-meshheading:1372377-Flow Cytometry,
pubmed-meshheading:1372377-Humans,
pubmed-meshheading:1372377-Hyperthermia, Induced,
pubmed-meshheading:1372377-Killer Cells, Natural,
pubmed-meshheading:1372377-Leukocyte Count,
pubmed-meshheading:1372377-Lymphocytes,
pubmed-meshheading:1372377-Male,
pubmed-meshheading:1372377-Middle Aged,
pubmed-meshheading:1372377-Phytohemagglutinins,
pubmed-meshheading:1372377-Preoperative Care,
pubmed-meshheading:1372377-Radiotherapy Dosage
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Influence of preoperative treatment and surgical operation on immune function of patients with esophageal carcinoma.
|
| pubmed:affiliation |
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
|
| pubmed:publicationType |
Journal Article
|