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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
1992-4-13
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pubmed:databankReference |
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pubmed:abstractText |
Insulin-like growth factor 1 (IGF-1) regulates growth of the brain. In order to characterize the variant IGF-1 present in human fetal brain we have determined the cDNA sequence for human fetal brain IGF-1. Using PCR to amplify cDNA obtained from isolated human fetal brain mRNA, two cDNA sequences encoding precursor proteins which correspond to IGF-1a and IGF-1b were obtained. This is the first characterisation of IGF-1 and its IGF-1a and IGF-1b precursors in the nervous system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0169-328X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
275-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1372070-Amino Acid Sequence,
pubmed-meshheading:1372070-Base Sequence,
pubmed-meshheading:1372070-Cerebral Cortex,
pubmed-meshheading:1372070-DNA,
pubmed-meshheading:1372070-Fetus,
pubmed-meshheading:1372070-Gestational Age,
pubmed-meshheading:1372070-Humans,
pubmed-meshheading:1372070-Insulin-Like Growth Factor I,
pubmed-meshheading:1372070-Molecular Sequence Data,
pubmed-meshheading:1372070-Poly A,
pubmed-meshheading:1372070-RNA,
pubmed-meshheading:1372070-RNA, Messenger,
pubmed-meshheading:1372070-Sequence Homology, Nucleic Acid
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pubmed:year |
1992
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pubmed:articleTitle |
Characterization of two cDNAs encoding insulin-like growth factor 1 (IGF-1) in the human fetal brain.
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pubmed:affiliation |
Karolinska Institute's Department of Pathology, Karolinska Hospital, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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