| pubmed-article:1372038 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C0037224 | lld:lifeskim |
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| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C1420433 | lld:lifeskim |
| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C1424666 | lld:lifeskim |
| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C1415887 | lld:lifeskim |
| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C1419040 | lld:lifeskim |
| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C0598086 | lld:lifeskim |
| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C0598388 | lld:lifeskim |
| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C1527177 | lld:lifeskim |
| pubmed-article:1372038 | lifeskim:mentions | umls-concept:C0441513 | lld:lifeskim |
| pubmed-article:1372038 | pubmed:dateCreated | 1992-4-16 | lld:pubmed |
| pubmed-article:1372038 | pubmed:abstractText | We have previously shown that immunization with solid matrix-antigen-antibody (SMAA) complexes induces both vigorous humoral and cell-mediated immune responses and have suggested that this method of vaccination may be developed for use in humans, and potentially as a vaccine against AIDS. Here we demonstrate that a small oligopeptide can act as a tag for the construction of SMAA complexes using a tag-specific monoclonal antibody and tag-linked antigens. We show that a 14-amino acid oligopeptide, present in the phospho (P) and V proteins of simian virus 5 (SV5), retains its antigenicity when attached to the C terminus of three 'foreign' proteins [p27 and gp110 of simian immunodeficiency virus (SIV) and glutathione S-transferase] such that these proteins can be incorporated into SMAA complexes using a monoclonal antibody (MAb) that was originally raised against the native SV5 P and V proteins. Mice were immunized with SMAA complexes containing recombinant p27-TAG and MAbs have been isolated that recognized native SIV p27. The significance of these results in terms of the development of SMAA complexes as human vaccines is discussed. | lld:pubmed |
| pubmed-article:1372038 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1372038 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1372038 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1372038 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1372038 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:1372038 | pubmed:issn | 0022-1317 | lld:pubmed |
| pubmed-article:1372038 | pubmed:author | pubmed-author:HankeTT | lld:pubmed |
| pubmed-article:1372038 | pubmed:author | pubmed-author:RandallR ERE | lld:pubmed |
| pubmed-article:1372038 | pubmed:author | pubmed-author:SzawlowskiPP | lld:pubmed |
| pubmed-article:1372038 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1372038 | pubmed:volume | 73 ( Pt 3) | lld:pubmed |
| pubmed-article:1372038 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1372038 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1372038 | pubmed:pagination | 653-60 | lld:pubmed |
| pubmed-article:1372038 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1372038 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1372038 | pubmed:articleTitle | Construction of solid matrix-antibody-antigen complexes containing simian immunodeficiency virus p27 using tag-specific monoclonal antibody and tag-linked antigen. | lld:pubmed |
| pubmed-article:1372038 | pubmed:affiliation | Department of Biochemistry and Microbiology, University of St Andrews, Fife, U.K. | lld:pubmed |
| pubmed-article:1372038 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1372038 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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