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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-4-1
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pubmed:databankReference |
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pubmed:abstractText |
In this study, we demonstrate that T cell lines specific for a synthetic peptide representing sequence 87 to 99 of myelin basic protein (MBP) are encephalitogenic in Lewis rats. However, unlike syngeneic T cells specific for MBP residues 68 to 88 which exclusively use V beta 8 in their antigen receptors, these cells do not. None of the 10 T cell lines and T hybridomas specific for MBP (87-99) used V beta 8 in their T cell receptors. Our results document for the first time that rat encephalitogenic T cells do not exclusively use V beta 8 in T cell receptors that rat encephalitogenic T cells specific for MBP (87-99) are heterogeneous and that MBP (87-99) contains at least two epitopes for rat T cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0014-2980
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
591-4
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1371473-Amino Acid Sequence,
pubmed-meshheading:1371473-Animals,
pubmed-meshheading:1371473-Base Sequence,
pubmed-meshheading:1371473-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:1371473-Epitopes,
pubmed-meshheading:1371473-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:1371473-Hybridomas,
pubmed-meshheading:1371473-Molecular Sequence Data,
pubmed-meshheading:1371473-Myelin Basic Proteins,
pubmed-meshheading:1371473-Oligodeoxyribonucleotides,
pubmed-meshheading:1371473-Polymerase Chain Reaction,
pubmed-meshheading:1371473-Rats,
pubmed-meshheading:1371473-Rats, Inbred Lew,
pubmed-meshheading:1371473-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:1371473-T-Lymphocyte Subsets
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pubmed:year |
1992
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pubmed:articleTitle |
Characterization of rat encephalitogenic T cells bearing non-V beta 8 T cell receptors.
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pubmed:affiliation |
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38101.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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