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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5045
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pubmed:dateCreated |
1992-3-19
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pubmed:abstractText |
L-arginine causes insulin release from pancreatic B cells. Data from three model systems support the hypothesis that L-arginine-derived nitrogen oxides (NOs) mediate insulin release stimulated by L-arginine in the presence of D-glucose and by the hypoglycemic drug tolbutamide. The formation of NO in pancreatic B cells was detected both chemically and by the NO-induced accumulation of guanosine 3',5'-monophosphate. NG-substituted L-arginine analogs inhibited the release of both insulin and NO. Protein immunoblot and histochemical analysis with antiserum to type I NO synthase suggest that the formation of NO in pancreatic B cells is catalyzed by an NADPH- (reduced form of nicotinamide adenine dinucleotide phosphate), Ca2+/calmodulin-dependent type I NO synthase of about 150 kilodaltons.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acid Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Calmodulin,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/NADP,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroarginine,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrogen Oxides,
http://linkedlifedata.com/resource/pubmed/chemical/omega-N-Methylarginine
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
255
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
721-3
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1371193-Amino Acid Oxidoreductases,
pubmed-meshheading:1371193-Animals,
pubmed-meshheading:1371193-Arginine,
pubmed-meshheading:1371193-Calcium,
pubmed-meshheading:1371193-Calmodulin,
pubmed-meshheading:1371193-Cell Line,
pubmed-meshheading:1371193-Cyclic GMP,
pubmed-meshheading:1371193-Enzyme Activation,
pubmed-meshheading:1371193-Glucose,
pubmed-meshheading:1371193-Guanylate Cyclase,
pubmed-meshheading:1371193-Insulin,
pubmed-meshheading:1371193-Islets of Langerhans,
pubmed-meshheading:1371193-NADP,
pubmed-meshheading:1371193-Nitric Oxide Synthase,
pubmed-meshheading:1371193-Nitroarginine,
pubmed-meshheading:1371193-Nitrogen Oxides,
pubmed-meshheading:1371193-Rats,
pubmed-meshheading:1371193-omega-N-Methylarginine
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pubmed:year |
1992
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pubmed:articleTitle |
Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides.
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pubmed:affiliation |
Department of Pharmacology, Northwestern University Medical School, Chicago, IL 60611.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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