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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
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pubmed:dateCreated |
1992-3-3
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|
pubmed:abstractText |
Three days after unilateral hypoxic-ischemic injury in infant rats insulin-like growth factor 1 (IGF-1) production by astrocytes was enhanced in the injured region. This was associated with increased expression of mRNA for IGF binding protein-3 but not for binding protein-1. In adult rats a single lateral cerebroventricular injection of IGF-1 two hours following a similar injury markedly reduced neuronal loss. It is suggested that endogenous IGF-1 is neurotrophic and that centrally administered IGF-1 may have therapeutic potential for brain injury.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jan
|
|
pubmed:issn |
0006-291X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
31
|
|
pubmed:volume |
182
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
593-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1370886-Animals,
pubmed-meshheading:1370886-Anoxia,
pubmed-meshheading:1370886-Astrocytes,
pubmed-meshheading:1370886-Brain,
pubmed-meshheading:1370886-Brain Ischemia,
pubmed-meshheading:1370886-Carrier Proteins,
pubmed-meshheading:1370886-Cerebral Ventricles,
pubmed-meshheading:1370886-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:1370886-Insulin-Like Growth Factor I,
pubmed-meshheading:1370886-Neurons,
pubmed-meshheading:1370886-RNA, Messenger,
pubmed-meshheading:1370886-Rats
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pubmed:year |
1992
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pubmed:articleTitle |
A role for IGF-1 in the rescue of CNS neurons following hypoxic-ischemic injury.
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pubmed:affiliation |
Department of Paediatrics, University of Auckland, New Zealand.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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