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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-2-20
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pubmed:abstractText |
Two properties were found to distinguish neuronal from muscle nicotinic acetylcholine receptors (nAChRs). First, neuronal nAChRs have a greater Ca2+ permeability. The high Ca2+ flux through neuronal nAChRs activates a Ca(2+)-dependent Cl- conductance, and the Ca2+ to Cs+ permeability ratio (PCa/PCs) is 7 times greater for neuronal than for muscle nAChRs. A second difference between the receptor types is that neuronal nAChRs are potently modulated by physiological levels of external Ca2+. Neuronal nAChR currents are enhanced by external Ca2+ in a dose-dependent manner. The results indicate that changes in extracellular Ca2+ modulate neuronal nAChRs and may modulate cholinergic synapses in the CNS. Also, activation of neuronal nAChRs produces a significant influx of Ca2+ that could be an important intracellular signal.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-34
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1370370-Adrenal Glands,
pubmed-meshheading:1370370-Animals,
pubmed-meshheading:1370370-Calcium,
pubmed-meshheading:1370370-Cattle,
pubmed-meshheading:1370370-Cesium,
pubmed-meshheading:1370370-Chlorides,
pubmed-meshheading:1370370-Chromaffin System,
pubmed-meshheading:1370370-Electric Conductivity,
pubmed-meshheading:1370370-Kinetics,
pubmed-meshheading:1370370-Membrane Potentials,
pubmed-meshheading:1370370-Mice,
pubmed-meshheading:1370370-Muscles,
pubmed-meshheading:1370370-Neurons,
pubmed-meshheading:1370370-Oocytes,
pubmed-meshheading:1370370-Permeability,
pubmed-meshheading:1370370-RNA,
pubmed-meshheading:1370370-Receptors, Nicotinic,
pubmed-meshheading:1370370-Transfection,
pubmed-meshheading:1370370-Xenopus
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pubmed:year |
1992
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pubmed:articleTitle |
Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors.
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pubmed:affiliation |
Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030-3498.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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