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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-2-10
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pubmed:abstractText |
We describe a novel experimental system in mice for the study of ovarian autoimmune disease, a condition encountered in women with premature ovarian failure. The ovarian autoimmune disease is induced in B6AF1 mice by a 15-amino acid peptide (Cys-Ser-Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln-Ile-His-Gly-Pro-Arg) from mouse ZP3, the sperm-binding component of the zona pellucida that surrounds growing and mature oocytes. Whereas the peptide induces both T cell and antibody responses, adoptive transfer of CD4+ T cell lines derived from affected animals causes oophoritis without observable antibodies to the zona pellucida peptide. The primacy of the T cell response in the pathogenesis of disease is further substantiated by defining oophoritogenic peptides as small as eight amino acids (Asn-Ser-Ser-Ser-Ser-Gln-Phe-Gln) that do not elicit an antibody response to the full-length ZP3 peptide. The identification of a well characterized peptide as a causative agent of autoimmune oophoritis should facilitate understanding of the pathogenesis of this T cell-mediated autoimmune disease. Because the proteins of the zona pellucida are conserved among mammals (the mouse and human ZP3 proteins are 67% identical), this murine model may lead to better understanding of the pathogenesis of human autoimmune oophoritis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-1690843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-2104631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-2385582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-2479101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-2535821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-2761940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-2788921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-2842770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-2884155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-3052278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-3289410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-3294396,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-3295039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-3378665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-3548402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-3996750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-6131030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-6167991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-6682874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-6691297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-6853551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-6970639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-6998618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1370297-7380091
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
89
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
28-35
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1370297-Amino Acid Sequence,
pubmed-meshheading:1370297-Animals,
pubmed-meshheading:1370297-Antigens,
pubmed-meshheading:1370297-Autoimmune Diseases,
pubmed-meshheading:1370297-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1370297-Disease Models, Animal,
pubmed-meshheading:1370297-Egg Proteins,
pubmed-meshheading:1370297-Epitopes,
pubmed-meshheading:1370297-Female,
pubmed-meshheading:1370297-Glycoproteins,
pubmed-meshheading:1370297-Membrane Glycoproteins,
pubmed-meshheading:1370297-Mice,
pubmed-meshheading:1370297-Mice, Inbred Strains,
pubmed-meshheading:1370297-Molecular Sequence Data,
pubmed-meshheading:1370297-Oophoritis,
pubmed-meshheading:1370297-Ovarian Diseases,
pubmed-meshheading:1370297-Ovarian Follicle,
pubmed-meshheading:1370297-Receptors, Cell Surface,
pubmed-meshheading:1370297-Zona Pellucida
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pubmed:year |
1992
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pubmed:articleTitle |
Autoimmune disease of the ovary induced by a ZP3 peptide from the mouse zona pellucida.
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pubmed:affiliation |
Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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