Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1 Suppl
|
| pubmed:dateCreated |
1992-2-6
|
| pubmed:abstractText |
The long- and short-term relation of risk factors to sudden cardiac death (SCD) is examined in the Framingham heart study of 2,011 men and 2,534 women aged 35-70 at the fourth biennial exam. Risk factor measurements over the first four biennial exams were averaged and analyzed as predictors of the long-term occurrence of SCD over the ensuing 28 years using Kaplan-Meier survival curves and the Cox proportional hazards method. The relation of risk factors to the short-term risk of SCD was examined by relating risk factors at each biennium to incidence over the ensuing 2 years, using pooled logistic regression analyses. Over the 28 years of follow-up, 171 men and 80 women experienced SCDs. Women had a lower incidence than men at all ages, and even after adjusting for known risk factors, their SCD rate was only 32% of that in men. In the short term, women have an SCD rate that is 23% of that in men. Most of the modifiable or constitutional risk factors, including glucose intolerance, systolic blood pressure, body mass index, and cigarette smoking have a greater long-term than short-term net effect. This is less apparent in women. Electrocardiographic abnormalities such as left ventricular hypertrophy, intraventricular block, and nonspecific repolarization abnormality were better short-term predictors. In men, preexisting coronary heart disease conferred a 3.3-fold (risk factor-adjusted) increased long-term risk of SCD and 5.3-fold increased short-term risk. In women, the long-term risk is 1.9 and short-term risk is 2.8.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0009-7322
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
85
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
I11-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1370216-Adult,
pubmed-meshheading:1370216-Age Factors,
pubmed-meshheading:1370216-Aged,
pubmed-meshheading:1370216-Blood Pressure,
pubmed-meshheading:1370216-Cardiac Complexes, Premature,
pubmed-meshheading:1370216-Cohort Studies,
pubmed-meshheading:1370216-Death, Sudden, Cardiac,
pubmed-meshheading:1370216-Electrocardiography,
pubmed-meshheading:1370216-Female,
pubmed-meshheading:1370216-Forecasting,
pubmed-meshheading:1370216-Heart Diseases,
pubmed-meshheading:1370216-Humans,
pubmed-meshheading:1370216-Male,
pubmed-meshheading:1370216-Middle Aged,
pubmed-meshheading:1370216-Proportional Hazards Models,
pubmed-meshheading:1370216-Risk Factors,
pubmed-meshheading:1370216-Sex Factors,
pubmed-meshheading:1370216-Time Factors
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Long- and short-term risk of sudden coronary death.
|
| pubmed:affiliation |
Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, MA.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|