Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-1-6
pubmed:abstractText
Fetal embryonic fibroblasts attach and spread on thrombospondin (TSP). Adhesion is tight and focal adhesion plaques and "spots" are formed. We have investigated the receptors responsible for this adhesion. Unstimulated cells express the vitronectin receptor on their surface and this beta 3 integrin molecule contributes to adhesion. Another putative receptor for TSP, termed glycoprotein (GP) 88, which exists as a cytoplasmic pool in unstimulated cells becomes surface expressed when these cells are plated on TSP and localizes to areas of cell adhesion. Western blot analysis of cell lysate confirms GP88 as a TSP binding protein. Studies with fucoidan indicate that the heparan sulfate proteoglycan, known to function as a receptor for TSP, appears to contribute substantially to the TSP attachment of these cells and may be the receptor most important in the initial phases of TSP interaction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD, http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD36, http://linkedlifedata.com/resource/pubmed/chemical/Chondroitin Sulfate Proteoglycans, http://linkedlifedata.com/resource/pubmed/chemical/Heparan Sulfate Proteoglycans, http://linkedlifedata.com/resource/pubmed/chemical/Heparitin Sulfate, http://linkedlifedata.com/resource/pubmed/chemical/Integrins, http://linkedlifedata.com/resource/pubmed/chemical/Platelet Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Polysaccharides, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoadhesin, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vitronectin, http://linkedlifedata.com/resource/pubmed/chemical/Thrombospondins, http://linkedlifedata.com/resource/pubmed/chemical/fucoidan
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-4827
pubmed:author
pubmed:issnType
Print
pubmed:volume
198
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-92
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:1370062-Antibodies, Monoclonal, pubmed-meshheading:1370062-Antigens, CD, pubmed-meshheading:1370062-Antigens, CD36, pubmed-meshheading:1370062-Blotting, Western, pubmed-meshheading:1370062-Cell Adhesion, pubmed-meshheading:1370062-Cells, Cultured, pubmed-meshheading:1370062-Chondroitin Sulfate Proteoglycans, pubmed-meshheading:1370062-Embryo, Mammalian, pubmed-meshheading:1370062-Fibroblasts, pubmed-meshheading:1370062-Heparan Sulfate Proteoglycans, pubmed-meshheading:1370062-Heparitin Sulfate, pubmed-meshheading:1370062-Humans, pubmed-meshheading:1370062-Integrins, pubmed-meshheading:1370062-Kinetics, pubmed-meshheading:1370062-Platelet Membrane Glycoproteins, pubmed-meshheading:1370062-Polysaccharides, pubmed-meshheading:1370062-Receptors, Cytoadhesin, pubmed-meshheading:1370062-Receptors, Immunologic, pubmed-meshheading:1370062-Receptors, Vitronectin, pubmed-meshheading:1370062-Thrombospondins
pubmed:year
1992
pubmed:articleTitle
Adhesion to thrombospondin by human embryonic fibroblasts is mediated by multiple receptors and includes a role for glycoprotein 88 (CD36).
pubmed:affiliation
Institute of Medical and Veterinary Science, Adelaide, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't