Source:http://linkedlifedata.com/resource/pubmed/id/13679631
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2003-9-18
|
| pubmed:abstractText |
The Fas/FasL system has been suggested to play an important role in the establishment of immune privilege status for tumors by inducing Fas-mediated apoptosis in tumor-specific lymphocytes. However, the role of cell-surface expressed FasL in tumor cell protection has recently become controversial. Our laboratory has focused on the study of the role of the Fas/FasL system in the normal tissue remodeling of the female reproductive tract and in immune-privileged organs. Our studies have demonstrated a connection between sex hormones and the regulation of the Fas/FasL pathway in immune and reproductive cells. More recently, we have investigated the resistance of tumor cells to Fas-mediated apoptosis. We have also characterized a new form of FasL, different from the classical membranal form, which is secreted by ovarian cancer cells. In this review we describe the main techniques used in these studies.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
1073-6085
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
19-30
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:13679631-Antigens, CD95,
pubmed-meshheading:13679631-Apoptosis,
pubmed-meshheading:13679631-Blotting, Western,
pubmed-meshheading:13679631-Cell Survival,
pubmed-meshheading:13679631-Culture Techniques,
pubmed-meshheading:13679631-Fas Ligand Protein,
pubmed-meshheading:13679631-Female,
pubmed-meshheading:13679631-Flow Cytometry,
pubmed-meshheading:13679631-Humans,
pubmed-meshheading:13679631-Immunohistochemistry,
pubmed-meshheading:13679631-Immunologic Surveillance,
pubmed-meshheading:13679631-Membrane Glycoproteins,
pubmed-meshheading:13679631-Microscopy, Fluorescence,
pubmed-meshheading:13679631-Models, Biological,
pubmed-meshheading:13679631-Neoplasms,
pubmed-meshheading:13679631-Ovarian Neoplasms,
pubmed-meshheading:13679631-Tumor Cells, Cultured,
pubmed-meshheading:13679631-Tumor Escape
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
The Fas/Fas ligand system and cancer: immune privilege and apoptosis.
|
| pubmed:affiliation |
Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, CT 06520, USA.
|
| pubmed:publicationType |
Journal Article,
Review
|