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rdf:type |
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lifeskim:mentions |
umls-concept:C0026809,
umls-concept:C0140186,
umls-concept:C0242726,
umls-concept:C0332161,
umls-concept:C0684336,
umls-concept:C0870186,
umls-concept:C0871261,
umls-concept:C0997031,
umls-concept:C1018911,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
6-7
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pubmed:dateCreated |
2003-9-18
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pubmed:abstractText |
We investigated the effect of Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang), a Japanese herbal medicine, and found that 1000 mg/kg p.o. improved the scopolamine-induced impairment of passive avoidance response in mice. Further, the same dose of Ninjin-yoei-to enhanced oxotremorine-induced tremors in mice. The water extract of Polygalae radix, one of the constituent herbs of Ninjin-yoei-to, at a dose of 100 mg/kg significantly improved the scopolamine-induced impairment of passive avoidance response and enhanced oxotremorine-induced tremors in mice. Moreover, the enhancement of oxotremorine-induced tremors by Ninjin-yoei-to (1000 mg/kg) and Polygalae radix (100 mg/kg) was completely antagonized by pretreatment of scopolamine hydrobromide (0.5 mg/kg). These results suggest that Ninjin-yoei-to may improve the scopolamine-induced impairment of passive avoidance response by enhancing the cholinergic system and that Polygalae radix may be involved in the action of Ninjin-yoei-to.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0944-7113
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
467-73
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:13678229-Administration, Oral,
pubmed-meshheading:13678229-Animals,
pubmed-meshheading:13678229-Behavior, Animal,
pubmed-meshheading:13678229-Dose-Response Relationship, Drug,
pubmed-meshheading:13678229-Drugs, Chinese Herbal,
pubmed-meshheading:13678229-Immunologic Factors,
pubmed-meshheading:13678229-Japan,
pubmed-meshheading:13678229-Male,
pubmed-meshheading:13678229-Medicine, Traditional,
pubmed-meshheading:13678229-Mice,
pubmed-meshheading:13678229-Muscarinic Agonists,
pubmed-meshheading:13678229-Oxotremorine,
pubmed-meshheading:13678229-Panax,
pubmed-meshheading:13678229-Phytotherapy,
pubmed-meshheading:13678229-Plant Extracts,
pubmed-meshheading:13678229-Polygala,
pubmed-meshheading:13678229-Scopolamine Hydrobromide,
pubmed-meshheading:13678229-Tremor
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pubmed:year |
2003
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pubmed:articleTitle |
Ninjin-yoei-to (Ren-Shen-Yang-Rong-Tang) and Polygalae radix improves scopolamine-induced impairment of passive avoidance response in mice.
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pubmed:affiliation |
Medicinal Evaluation Laboratories, Tsumura & Co., Yoshiwara, Ami-machi Inashiki-gun, Ibaraki, Japan.
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pubmed:publicationType |
Journal Article
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