Linked Life Data

136742

Source:http://linkedlifedata.com/resource/pubmed/id/136742

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1977-1-29
pubmed:abstractText
The thymuses of 14-day-old CBA mouse embryos cultured for 14 days in organ cultures supplemented with mouse serum contained lymphocytes that were highly reactive to the mitogens concanavalin A (Con A) and leukoagglutinin (LA) and to irradiated allogeneic spleen cells in vitro. In contrast, thymocytes derived from fetal-calf-serum-supplemented organ cultures displayed much weaker responses to the two mitogens and little or no response to the allogeneic spleen cells. Control thymocytes obtained from 1-month-old CBA mice responded well to Con A but not to LA. The responses of these cells to allogeneic spleen cells were delayed compared with the organ-culture-derived cells, which responded promptly, with a maximum already on culture day 2-3. The results demonstrate that the organ culture system provides a convenient model for further study of the generation of immunoreactive cells in the mouse thymus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
901-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Role of the thymus in generation of lymphocyte functions. I. Demonstration of lymphocytes reactive to mitogens and allogeneic cells in the embryonic mouse thymus in organ culture.
pubmed:publicationType
Journal Article