Linked Life Data

1367120

Source:http://linkedlifedata.com/resource/pubmed/id/1367120

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1991-6-12
pubmed:abstractText
Toxicity testing is required for new chemicals being introduced onto the market. The use of animals in evaluating chemical safety is costly and time consuming. Furthermore, there is the ethical need to develop alternative methods to reduce the required number of animals. The new in vitro assays offer numerous advantages such as speed, reproducibility and control of test conditions, and increased sensitivity. Although the dermal irritation assays might be substituted by the in vitro tests in the near future (Duffy, 1989), much work is required to evaluate organ toxicity with in vitro methods. We present data regarding the use of Balb/3T3 mice fibroblasts and primary rat hepatocytes as test systems for in vitro toxicity. The end-points we have analysed are total protein content, dye accumulation in lysosomes, reductase mitochondrial activity, intracellular content and leakage of enzymes into the medium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
B
pubmed:status
MEDLINE
pubmed:issn
0920-9069
pubmed:author
pubmed:issnType
Print
pubmed:volume
5 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
51-4
pubmed:dateRevised
2008-10-9
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Alternative methods in toxicology tests: in vitro toxicity.
pubmed:affiliation
Roma Toxicology Centre, Department of Genetic and Cellular Toxicology, Pomezia.
pubmed:publicationType
Journal Article