| pubmed-article:1365646 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1365646 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:1365646 | lifeskim:mentions | umls-concept:C0001792 | lld:lifeskim |
| pubmed-article:1365646 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:1365646 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:1365646 | lifeskim:mentions | umls-concept:C0039245 | lld:lifeskim |
| pubmed-article:1365646 | lifeskim:mentions | umls-concept:C0733755 | lld:lifeskim |
| pubmed-article:1365646 | lifeskim:mentions | umls-concept:C0597198 | lld:lifeskim |
| pubmed-article:1365646 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:1365646 | lifeskim:mentions | umls-concept:C0450442 | lld:lifeskim |
| pubmed-article:1365646 | lifeskim:mentions | umls-concept:C0039725 | lld:lifeskim |
| pubmed-article:1365646 | lifeskim:mentions | umls-concept:C0205421 | lld:lifeskim |
| pubmed-article:1365646 | lifeskim:mentions | umls-concept:C1564278 | lld:lifeskim |
| pubmed-article:1365646 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:1365646 | pubmed:dateCreated | 1995-2-23 | lld:pubmed |
| pubmed-article:1365646 | pubmed:abstractText | The present study investigated the effects of dexmedetomidine (an alpha-2 adrenoceptor agonist), atipamezole (an alpha-2 adrenoceptor antagonist) and tacrine (an inhibitor of acetylcholinesterase) on the performance of adult and aged rats in a delayed non-matching to position task assessing spatial short-term memory. Most of the aged rats were impaired in the pretraining phases and in the acquisition of the non-delayed version of the task. After a substantial training period of the delayed version of the task, both adult and aged rats reached their asymptotic level of performance. Both adult and aged rats showed a decline in the percent correct responses at the longest delays in this task, and a delay independent decrease in the percent correct responses across the delays (0-30 s) was found in the group of aged rats (25-month-old) as compared to the adults (10-month-old). Dexmedetomidine (0.3, 1.0 or 3.0 micrograms/kg), atipamezole (0.03, 0.3 or 3.0 mg/kg) and tacrine (1.0 or 3.0 mg/kg) did not increase the percent correct responses in adult or aged rats. The highest doses of dexmedetomidine and tacrine decreased behavioural activity of rats during this short-term memory testing. Atipamezole (0.03 mg/kg) increased behavioural activity of rats. The results suggest that acute, systemic administrations of alpha-2 drugs or an anticholinesterase do not improve short-term memory in rats. | lld:pubmed |
| pubmed-article:1365646 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1365646 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365646 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1365646 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365646 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365646 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365646 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365646 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365646 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365646 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365646 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1365646 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1365646 | pubmed:issn | 0033-3158 | lld:pubmed |
| pubmed-article:1365646 | pubmed:author | pubmed-author:RiekkinenP... | lld:pubmed |
| pubmed-article:1365646 | pubmed:author | pubmed-author:SirviöJJ | lld:pubmed |
| pubmed-article:1365646 | pubmed:author | pubmed-author:RiekkinenPPJr | lld:pubmed |
| pubmed-article:1365646 | pubmed:author | pubmed-author:HaapalinnaAA | lld:pubmed |
| pubmed-article:1365646 | pubmed:author | pubmed-author:HarjuMM | lld:pubmed |
| pubmed-article:1365646 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1365646 | pubmed:volume | 109 | lld:pubmed |
| pubmed-article:1365646 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1365646 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1365646 | pubmed:pagination | 127-33 | lld:pubmed |
| pubmed-article:1365646 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:1365646 | pubmed:meshHeading | pubmed-meshheading:1365646-... | lld:pubmed |
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| pubmed-article:1365646 | pubmed:meshHeading | pubmed-meshheading:1365646-... | lld:pubmed |
| pubmed-article:1365646 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1365646 | pubmed:articleTitle | Comparative effects of alpha-2 receptor agents and THA on the performance of adult and aged rats in the delayed non-matching to position task. | lld:pubmed |
| pubmed-article:1365646 | pubmed:affiliation | Department of Neurology, University of Kuopio, Finland. | lld:pubmed |
| pubmed-article:1365646 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1365646 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1365646 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
