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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1995-2-23
|
| pubmed:abstractText |
The present study investigated the effects of dexmedetomidine (an alpha-2 adrenoceptor agonist), atipamezole (an alpha-2 adrenoceptor antagonist) and tacrine (an inhibitor of acetylcholinesterase) on the performance of adult and aged rats in a delayed non-matching to position task assessing spatial short-term memory. Most of the aged rats were impaired in the pretraining phases and in the acquisition of the non-delayed version of the task. After a substantial training period of the delayed version of the task, both adult and aged rats reached their asymptotic level of performance. Both adult and aged rats showed a decline in the percent correct responses at the longest delays in this task, and a delay independent decrease in the percent correct responses across the delays (0-30 s) was found in the group of aged rats (25-month-old) as compared to the adults (10-month-old). Dexmedetomidine (0.3, 1.0 or 3.0 micrograms/kg), atipamezole (0.03, 0.3 or 3.0 mg/kg) and tacrine (1.0 or 3.0 mg/kg) did not increase the percent correct responses in adult or aged rats. The highest doses of dexmedetomidine and tacrine decreased behavioural activity of rats during this short-term memory testing. Atipamezole (0.03 mg/kg) increased behavioural activity of rats. The results suggest that acute, systemic administrations of alpha-2 drugs or an anticholinesterase do not improve short-term memory in rats.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-2 Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Imidazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Medetomidine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-2,
http://linkedlifedata.com/resource/pubmed/chemical/Tacrine,
http://linkedlifedata.com/resource/pubmed/chemical/atipamezole
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0033-3158
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
109
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
127-33
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:1365646-Adrenergic alpha-2 Receptor Agonists,
pubmed-meshheading:1365646-Adrenergic alpha-2 Receptor Antagonists,
pubmed-meshheading:1365646-Adrenergic alpha-Agonists,
pubmed-meshheading:1365646-Adrenergic alpha-Antagonists,
pubmed-meshheading:1365646-Aging,
pubmed-meshheading:1365646-Animals,
pubmed-meshheading:1365646-Brain Chemistry,
pubmed-meshheading:1365646-Conditioning, Operant,
pubmed-meshheading:1365646-Imidazoles,
pubmed-meshheading:1365646-Male,
pubmed-meshheading:1365646-Medetomidine,
pubmed-meshheading:1365646-Memory, Short-Term,
pubmed-meshheading:1365646-Rats,
pubmed-meshheading:1365646-Rats, Wistar,
pubmed-meshheading:1365646-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:1365646-Reinforcement Schedule,
pubmed-meshheading:1365646-Space Perception,
pubmed-meshheading:1365646-Tacrine
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Comparative effects of alpha-2 receptor agents and THA on the performance of adult and aged rats in the delayed non-matching to position task.
|
| pubmed:affiliation |
Department of Neurology, University of Kuopio, Finland.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|