Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-9-1
pubmed:abstractText
Aging is accompanied by a decline in immune reactivity which to a major extent can be attributed to changes at the level of regulatory CD4+ T cells. In addition to evidence pointing to intrinsic defects, resulting in improper responsiveness of lymphocytes, it is likely that many age-related phenomena can be explained by a changed composition of the T cell compartment. Most likely as a consequence of thymic involution, the fraction of naive T cells in the periphery decreases, resulting in poor responses to neoantigens in particular. Moreover, due to antigenic exposure the fraction of memory cells increases. It is likely that, regardless of their phenotype, cells from aged individuals are subject to intrinsic defects or to immunosuppression, resulting in a lower responsiveness. As far as CD4+ T cells are concerned, recent studies have demonstrated that naive and memory cells behave differently with regard to activation requirements and lymphokine production. Age-related changes in T cell reactivity will be discussed in the context of these observations.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0254-9670
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-202
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Age-related changes in immune reactivity: the influence of intrinsic defects and of a changed composition of the CD4+ T cell compartment.
pubmed:affiliation
Section of Immunology, TNO Institute of Ageing and Vascular Research, Leiden, The Netherlands.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't