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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1993-3-2
|
| pubmed:abstractText |
This study was designed to test the in-vitro activity of four oral antibiotics against the four microorganisms most frequently isolated in acute otitis media: beta-lactamase-positive Haemophilus influenzae (N = 10), beta-lactamase-positive Moraxella catarrhalis (N = 10), penicillin-sensitive Streptococcus pneumoniae (N = 11) and methicillin-sensitive Staphylococcus aureus (N = 10), by the bactericidal curve method. Bactericidal kinetics were determined for concentrations of antibiotic equivalent to those found in the middle ear after treatment: amoxycillin-clavulanic acid (2.5 mg l-1/0.6 mg l-1 and 2.5 mg l-1/1.2 mg l-1), cefaclor (1 mg l-1), erythromycin (0.5 mg l-1) and erythromycin/sulfisoxazole (0.2/3 mg l-1). The inoculum was of 10(6) colony-forming units (cfu) ml-1. The bacterial counts were performed after 5 h and 24 h using a spiral inoculator system. The results showed that amoxycillin-clavulanic acid had rapid bactericidal activity (< 24 h) on the tested organisms at each of the doses used (reduction < or = 3 log10 cfu ml-1) which was not observed with the other antibiotics at either 5 or 24 h. Erythromycin alone or combined with sulfisoxazole had a bacteriostatic effect on Moraxella catarrhalis and Streptococcus pneumoniae but not on Haemophilus influenzae or Staphylococcus aureus. Cefaclor had no bactericidal action under these conditions.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amoxicillin,
http://linkedlifedata.com/resource/pubmed/chemical/Amoxicillin-Potassium Clavulanate...,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cefaclor,
http://linkedlifedata.com/resource/pubmed/chemical/Clavulanic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Erythromycin,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfisoxazole
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0195-6701
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
22 Suppl A
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
89-97
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1362754-Acute Disease,
pubmed-meshheading:1362754-Amoxicillin,
pubmed-meshheading:1362754-Amoxicillin-Potassium Clavulanate Combination,
pubmed-meshheading:1362754-Anti-Bacterial Agents,
pubmed-meshheading:1362754-Cefaclor,
pubmed-meshheading:1362754-Child, Preschool,
pubmed-meshheading:1362754-Clavulanic Acids,
pubmed-meshheading:1362754-Colony Count, Microbial,
pubmed-meshheading:1362754-Drug Therapy, Combination,
pubmed-meshheading:1362754-Erythromycin,
pubmed-meshheading:1362754-Gram-Negative Bacteria,
pubmed-meshheading:1362754-Gram-Positive Bacteria,
pubmed-meshheading:1362754-Haemophilus influenzae,
pubmed-meshheading:1362754-Humans,
pubmed-meshheading:1362754-Infant,
pubmed-meshheading:1362754-Microbial Sensitivity Tests,
pubmed-meshheading:1362754-Moraxella (Branhamella) catarrhalis,
pubmed-meshheading:1362754-Otitis Media,
pubmed-meshheading:1362754-Staphylococcus aureus,
pubmed-meshheading:1362754-Streptococcus pneumoniae,
pubmed-meshheading:1362754-Sulfisoxazole
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
In-vitro bactericidal activity of four oral antibiotics against pathogens responsible for acute otitis media in children.
|
| pubmed:affiliation |
Hôpital Robert Debré, Service de Bactériologie, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|