Linked Life Data

1362406

Source:http://linkedlifedata.com/resource/pubmed/id/1362406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
1993-2-17
pubmed:abstractText
We have analyzed DNA marker typing data contributed by six independent groups to estimate the pairwise genetic distances between these markers and the locus for multiple endocrine neoplasia type 2A (MEN 2A). We used LIPED to calculate these distances for female, male, and sex-average linkage maps and to determine the corresponding LOD scores. The preliminary analyses of this large data set (89 MEN 2A families and five non-MEN 2A references families, with 1,934 total individuals) are reported here. These refined estimates of the genetic map in this region will aid in the assignment of presymptomatic diagnoses. This study clearly points out the limitation of pairwise linkage analysis in further refining the position of MEN2A in this small region of chromosome 10. Further refinement of the genetic map position of MEN2A will be best accomplished by finding, verifying, and accurately mapping crossovers in specific families.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0018-0416
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:geneSymbol
MEN2A
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
205-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
A preliminary analysis of consortium data for markers tightly linked to multiple endocrine neoplasia type 2A.
pubmed:affiliation
Department of Genetics, Yale University, New Haven, CT.
pubmed:publicationType
Journal Article