Linked Life Data

1362119

Source:http://linkedlifedata.com/resource/pubmed/id/1362119

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1993-2-9
pubmed:abstractText
This study compares the efficacy and side effects of omeprazole and regular- and double-dose nizatidine in the treatment of duodenal ulcers. Duodenal ulcer healing rates in these three groups (omeprazole, 20 mg qd; nizatidine, 300 mg hs and 600 mg hs) were 81.8%, 19% and 30%, respectively, after two weeks of therapy; and 90.5%, 70% and 84.2%, respectively, after four weeks of treatment. Omeprazole had a significantly better healing rate than nizatidine, 300 mg or 600 mg, after two weeks of treatment (p < 0.01), but not after four weeks of treatment. Omeprazole relieved the ulcer pain sooner than nizatidine (p < 0.05). Smoking decreased the duodenal ulcer healing rate in the omeprazole group, but not in the nizatidine groups. Clinical features, such as sex, age, alcohol consumption, ulcer size, past history of upper gastrointestinal bleeding and duration of peptic ulcer history, did not collate with the healing rate. Patients with double-dose nizatidine did not show any benefits over those with a regular dose in this study. Adverse effects were minor, and there were no significant changes in biochemistry after therapy in these three groups of patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0929-6646
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
793-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Comparison of omeprazole and nizatidine in the treatment of duodenal ulcers.
pubmed:affiliation
Department of Internal Medicine, Kaohsiung Medical College, Taiwan, R.O.C.
pubmed:publicationType
Journal Article, Comparative Study