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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1993-1-6
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pubmed:abstractText |
We investigated whether excitatory amino acids acting at the N-methyl-D-aspartate (NMDA) subtype of the L-glutamate receptor contribute to the dopaminergic neurotoxicity induced by systemic administration of the Parkinson's syndrome-inducing toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in C57Bl/6 mice. The MPTP-regimen chosen (30-40 mg/kg body weight subcutaneously) resulted a 60-70% depletion of striatal dopamine (DA) content and a 20% reduction of tyrosine hydroxylase immunoreactive (TH-IR) cells in the substantia nigra pars compacta 20 days after administration. Repeated systemic coadministration of the non-competitive NMDA receptor antagonist MK-801 or of the novel competitive NMDA receptor antagonist CGP 40116 did not protect against MPTP-induced striatal DA depletion 20 days after toxin administration. Additionally, no short-term protective effects of MK-801 on striatal DA content were observed 24, 48, and 96 h, respectively, after exposure to MPTP. A slight and non-significant attenuation (approximately 10%) of the MPTP-induced decrease in the number of nigral TH-IR cells was observed after MK-801- and CGP 40116-treatment. We conclude that neurotoxicity of systemically administered MPTP is not substantially antagonized by NMDA receptor antagonists in mice.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Methyl-4-phenyl-1,2,3,6-tetrahydro...,
http://linkedlifedata.com/resource/pubmed/chemical/2-Amino-5-phosphonovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/2-amino-4-methyl-5-phosphono-3-pente...,
http://linkedlifedata.com/resource/pubmed/chemical/Catecholamines,
http://linkedlifedata.com/resource/pubmed/chemical/Dizocilpine Maleate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
592
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-83
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1360317-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,
pubmed-meshheading:1360317-2-Amino-5-phosphonovalerate,
pubmed-meshheading:1360317-Animals,
pubmed-meshheading:1360317-Behavior, Animal,
pubmed-meshheading:1360317-Catecholamines,
pubmed-meshheading:1360317-Corpus Striatum,
pubmed-meshheading:1360317-Dizocilpine Maleate,
pubmed-meshheading:1360317-Immunohistochemistry,
pubmed-meshheading:1360317-MPTP Poisoning,
pubmed-meshheading:1360317-Male,
pubmed-meshheading:1360317-Mice,
pubmed-meshheading:1360317-Mice, Inbred C57BL,
pubmed-meshheading:1360317-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:1360317-Substantia Nigra,
pubmed-meshheading:1360317-Tyrosine 3-Monooxygenase
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pubmed:year |
1992
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pubmed:articleTitle |
Do NMDA receptor antagonists protect against MPTP-toxicity? Biochemical and immunocytochemical analyses in black mice.
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pubmed:affiliation |
Klinikum Grosshadern, Department of Neurology, Ludwig-Maximilians-University, München, FRG.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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