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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1992-12-9
|
| pubmed:abstractText |
Methyl 5-aminosalicylate hydrochloride (M-5-AS) at the dosages of 21, 42, 209, and 417 mg.kg-1.d-1 ig to mice during d 6-15 of pregnancy, no obvious effects on the placenta, fetus weight, sex differentiation, external appearance, visceral, and skeletal development were observed. In rats ig M-5-AS 56 and 556 mg.kg-1.d-1 produced no noticeable effects on the organogenesis or teratogenesis either. In mice and rats ig salicylazopyridine 410 and 1089 mg.kg-1.d-1 respectively no obvious teratogenicity was detected. However, aspirin 250 mg.kg-1.d-1 ig did bring about significant teratogenicity in rats.
|
| pubmed:language |
chi
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0253-9756
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
265-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1359731-Abnormalities, Drug-Induced,
pubmed-meshheading:1359731-Aminosalicylic Acids,
pubmed-meshheading:1359731-Animals,
pubmed-meshheading:1359731-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:1359731-Embryo Loss,
pubmed-meshheading:1359731-Embryonic and Fetal Development,
pubmed-meshheading:1359731-Female,
pubmed-meshheading:1359731-Fetal Death,
pubmed-meshheading:1359731-Mice,
pubmed-meshheading:1359731-Pregnancy,
pubmed-meshheading:1359731-Rats,
pubmed-meshheading:1359731-Rats, Inbred Strains,
pubmed-meshheading:1359731-Sulfasalazine
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
[Teratologic studies of methyl 5-aminosalicylate and salicylazopyridine].
|
| pubmed:affiliation |
Institute of Materia Medica, Kunming Pharmaceutical Factory, China.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|