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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1992-12-14
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pubmed:abstractText |
This study examines the effects of endotoxin on intestinal water and electrolyte transport in adult male rats. Endotoxin (1.55 mg/kg, intravenously) reduced in vivo colonic saline absorption 61% in 1 hour. In vitro unidirectional and net 22Na and 36Cl fluxes showed that endotoxin significantly decreased net colonic 22Na absorption compared with control colons (0.3 +/- 1.7 vs. 4.8 +/- 1.1 microEq/h x cm2). Although endotoxin had no significant effect on basal short circuit current (Isc) and conductance, 3H-inulin flux studies suggested an increase in colonic permeability. Isc responses to the 5'-cyclic adenosine monophosphate (cAMP)-dependent secretagogues prostaglandin E2 (1 mumol/L) and vasoactive intestinal peptide (0.1 mumol/L) were diminished by 80% and 50%, respectively. However, cytosolic cAMP-dependent protein kinase activity under basal and stimulated (6 mumol/L 8-bromo-cAMP) conditions was not altered by endotoxin treatment. The Isc responses to 10 mumol/L bethanechol, a Ca(2+)-dependent agonist, were not effected by endotoxin treatment. It was concluded that endotoxin significantly affects colonic transport function and may contribute to the development of diarrhea in inflammatory bowel diseases.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Bromo Cyclic Adenosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Bethanechol,
http://linkedlifedata.com/resource/pubmed/chemical/Bethanechol Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Chlorine,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Endotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Forskolin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium,
http://linkedlifedata.com/resource/pubmed/chemical/Theophylline,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoactive Intestinal Peptide
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1437-43
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1358740-8-Bromo Cyclic Adenosine Monophosphate,
pubmed-meshheading:1358740-Animals,
pubmed-meshheading:1358740-Bethanechol,
pubmed-meshheading:1358740-Bethanechol Compounds,
pubmed-meshheading:1358740-Biological Transport,
pubmed-meshheading:1358740-Chlorine,
pubmed-meshheading:1358740-Colon,
pubmed-meshheading:1358740-Diarrhea,
pubmed-meshheading:1358740-Dinoprostone,
pubmed-meshheading:1358740-Endotoxins,
pubmed-meshheading:1358740-Forskolin,
pubmed-meshheading:1358740-Ileum,
pubmed-meshheading:1358740-Insulin,
pubmed-meshheading:1358740-Jejunum,
pubmed-meshheading:1358740-Male,
pubmed-meshheading:1358740-Protein Kinases,
pubmed-meshheading:1358740-Rats,
pubmed-meshheading:1358740-Rats, Sprague-Dawley,
pubmed-meshheading:1358740-Sodium,
pubmed-meshheading:1358740-Theophylline,
pubmed-meshheading:1358740-Vasoactive Intestinal Peptide,
pubmed-meshheading:1358740-Water-Electrolyte Balance
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pubmed:year |
1992
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pubmed:articleTitle |
Endotoxin-induced alterations in rat colonic water and electrolyte transport.
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pubmed:affiliation |
University of Chicago, Department of Medicine, Illinois.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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