Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8824
|
| pubmed:dateCreated |
1992-11-2
|
| pubmed:abstractText |
There have been reported cases of long-term symptomless human immunodeficiency virus type 1 (HIV-1) infection, but it is not clear whether the benign course of infection was due to host, viral, or other unknown factors. During follow-up of subjects with transfusion-acquired HIV-1 infection in New South Wales, Australia, we identified a group of 6 subjects who had been infected through a single common donor. We were therefore able to study the contributions of various factors to the course of infection. Throughout follow-up (range 6.8-10.1 years after infection), 5 of the recipients and the donor (last follow-up 10.2 years after infection of the first recipient) remained clinically free of symptoms, with normal CD4 cell counts and no p24 antigenaemia. HIV-1 was isolated from only 1 recipient; the isolate did not induce syncytia in a SUPT1 co-culture assay and had a limited in-vitro host range. 1 infected recipient (who had received extensive immunosuppressive treatment for systemic lupus erythematosus) developed Pneumocystis carinii pneumonia and died 4.3 years after infection. The frequency of progression to AIDS or a CD4 cell count below 0.50 x 10(9)/l was significantly lower among the 6 subjects with a common donor (1/6) than among 101 other HIV-infected transfusion recipients for whom data from 7 years of follow-up were available (94/101; p less than 0.0001). These findings suggest that the subjects were infected by a less virulent strain of HIV-1. The identification of this group of subjects should stimulate a search for other similar groups, which will provide important information on the immunopathogenesis of HIV-1 disease.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0140-6736
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
340
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
863-7
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1357294-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:1357294-Adolescent,
pubmed-meshheading:1357294-Adult,
pubmed-meshheading:1357294-Aged,
pubmed-meshheading:1357294-Blood Donors,
pubmed-meshheading:1357294-Blood Transfusion,
pubmed-meshheading:1357294-CD4-CD8 Ratio,
pubmed-meshheading:1357294-CD4-Positive T-Lymphocytes,
pubmed-meshheading:1357294-Female,
pubmed-meshheading:1357294-HIV Core Protein p24,
pubmed-meshheading:1357294-HIV Infections,
pubmed-meshheading:1357294-HIV Seropositivity,
pubmed-meshheading:1357294-HIV-1,
pubmed-meshheading:1357294-Humans,
pubmed-meshheading:1357294-Longitudinal Studies,
pubmed-meshheading:1357294-Male,
pubmed-meshheading:1357294-Middle Aged,
pubmed-meshheading:1357294-T-Lymphocytes, Regulatory,
pubmed-meshheading:1357294-Virulence,
pubmed-meshheading:1357294-beta 2-Microglobulin
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Long-term symptomless HIV-1 infection in recipients of blood products from a single donor.
|
| pubmed:affiliation |
New South Wales Red Cross Blood Transfusion Service, Sydney, Australia.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|