135726

Source:http://linkedlifedata.com/resource/pubmed/id/135726

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0004561, umls-concept:C0023509, umls-concept:C0035820, umls-concept:C0086418, umls-concept:C0175727, umls-concept:C1548966
pubmed:issue	4
pubmed:dateCreated	1976-12-23
pubmed:abstractText	Four different combinations of one-way mixed lymphocyte reactions between human peripheral blood T and B lymphocytes (at a ratio of 1:1), purified by the E-rosetting technique, were carried our. A significant mixed lymphocyte reaction was observed only in a combination in which T lymphocytes, as responding cells, and B lymphocytes, as stimulating cells, were utilized. No significant mixed lymphocyte reaction was noted in the other three combinations of cells, using T or B lymphocytes as responders and T lymphocytes as stimulators, and also B lymphocytes as both responders and stimulators. Mixed lymphocyte reactions between T lymphocytes as responders (at constant concentration) and T and B lymphocytes as stimulators (varying proportions) showed that the response decreased proportionately with decreasing numbers of B cells and increasing numbers of T cells used as stimulators. Addition of increasing numbers of stimulating T cells to a constant number of stimulating B cells did not suppress or enhance the T-cell response to B cells. These observations indicate that the human peripheral blood T and B lymphocytes play an exclusive role as responding cells and stimulating cells, respectively.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-123598, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-130342, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4135582, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4263184, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4268100, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4268630, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4269624, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4270704, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4272924, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4273215, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4276467, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4399834, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4539312, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4580576, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-4943360, http://linkedlifedata.com/resource/pubmed/commentcorrection/135726-5055183
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0374672
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Oct
pubmed:issn	0019-2805
pubmed:author	pubmed-author:DadeyBB, pubmed-author:HanTT
pubmed:issnType	Print
pubmed:volume	31
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	643-8
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:135726-B-Lymphocytes, pubmed-meshheading:135726-Humans, pubmed-meshheading:135726-Leukocyte Count, pubmed-meshheading:135726-Lymphocyte Activation, pubmed-meshheading:135726-Lymphocyte Culture Test, Mixed, pubmed-meshheading:135726-T-Lymphocytes
pubmed:year	1976
pubmed:articleTitle	T and B lymphocytes. Exclusive role as responders and stimulators in human one-way mixed lymphocyte reaction.
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S.