| pubmed-article:1357002 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1357002 | lifeskim:mentions | umls-concept:C0521346 | lld:lifeskim |
| pubmed-article:1357002 | lifeskim:mentions | umls-concept:C0010674 | lld:lifeskim |
| pubmed-article:1357002 | lifeskim:mentions | umls-concept:C0021368 | lld:lifeskim |
| pubmed-article:1357002 | lifeskim:mentions | umls-concept:C0221908 | lld:lifeskim |
| pubmed-article:1357002 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:1357002 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:1357002 | lifeskim:mentions | umls-concept:C0052059 | lld:lifeskim |
| pubmed-article:1357002 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:1357002 | lifeskim:mentions | umls-concept:C0205148 | lld:lifeskim |
| pubmed-article:1357002 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:1357002 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:1357002 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:1357002 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:1357002 | pubmed:dateCreated | 1992-11-13 | lld:pubmed |
| pubmed-article:1357002 | pubmed:abstractText | Based on the knowledge that neutrophil elastase (NE) in cystic fibrosis (CF) epithelial lining fluid (ELF) can induce human bronchial epithelial cells to express the gene for interleukin 8 (IL-8), an 8.5-kD neutrophil chemoattractant, we have evaluated CF ELF for the presence of IL-8, and investigated the ability of aerosolized recombinant secretory leukoprotease inhibitor (rSLPI) to suppress NE, and hence IL-8, levels on the respiratory epithelial surface in CF. Enzyme-linked immunoassay revealed 21.9 +/- 4.8 nM IL-8 in CF ELF compared with none in normals. Active NE was detectable in ELF of all individuals with CF and was significantly decreased (P < 0.03) after aerosolization of rSLPI. Human bronchial epithelial cells exposed to CF ELF recovered before rSLPI therapy expressed IL-8 mRNA transcripts, but ELF recovered after rSLPI therapy induced far less bronchial epithelial cell IL-8 gene expression. Consistent with this, rSLPI aerosol therapy caused a marked reduction in CF ELF IL-8 levels (P < 0.05) and neutrophil number (P < 0.02). There was also a clear association between CF ELF active NE and IL-8 levels (r = 0.94). These data suggest that rSLPI therapy not only suppresses respiratory epithelial NE levels, but also breaks a cycle of inflammation on the CF epithelial surface. | lld:pubmed |
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| pubmed-article:1357002 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1357002 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:1357002 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1357002 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1357002 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:1357002 | pubmed:author | pubmed-author:NakamuraHH | lld:pubmed |
| pubmed-article:1357002 | pubmed:author | pubmed-author:BakerJ BJB | lld:pubmed |
| pubmed-article:1357002 | pubmed:author | pubmed-author:CrystalR GRG | lld:pubmed |
| pubmed-article:1357002 | pubmed:author | pubmed-author:CatalanoM AMA | lld:pubmed |
| pubmed-article:1357002 | pubmed:author | pubmed-author:WongW LWL | lld:pubmed |
| pubmed-article:1357002 | pubmed:author | pubmed-author:McElvaneyN... | lld:pubmed |
| pubmed-article:1357002 | pubmed:author | pubmed-author:BirrerPP | lld:pubmed |
| pubmed-article:1357002 | pubmed:author | pubmed-author:HébertC ACA | lld:pubmed |
| pubmed-article:1357002 | pubmed:author | pubmed-author:AlphonsoMM | lld:pubmed |
| pubmed-article:1357002 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1357002 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:1357002 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1357002 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1357002 | pubmed:pagination | 1296-301 | lld:pubmed |
| pubmed-article:1357002 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1357002 | pubmed:year | 1992 | lld:pubmed |
