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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
1992-11-18
|
| pubmed:abstractText |
We studied the haemodynamic effects of dopexamine hydrochloride, a beta 2-adrenergic agonist with dopaminergic (DA1) activity, in 20 patients with low cardiac output following surgery for coronary artery bypass grafting and/or valve replacement or repair. Following titration of four doses (1, 2, 4 and 6 micrograms.kg-1.min-1), the dose producing the optimal response was infused for up to 48 h (five patients). During the infusion, significant increases in cardiac index and stroke volume were accompanied by significant decreases in systemic vascular resistance. Heart rate increased significantly up to 6 h and thereafter returned to control levels. Mean blood pressure was reduced but did not fall below 60 mmHg. However, in five patients treated for 48 h mean blood pressure had returned to control levels. Unwanted effects (tachycardia and hypotension) were seen chiefly at higher doses, leading us to conclude that infusion rates of 4 micrograms.kg-1.min-1 or less will be useful in the treatment of low cardiac output following cardiac surgery.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0195-668X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1271-6
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1356772-Adrenergic Agonists,
pubmed-meshheading:1356772-Adult,
pubmed-meshheading:1356772-Aged,
pubmed-meshheading:1356772-Aortic Valve,
pubmed-meshheading:1356772-Cardiac Output, Low,
pubmed-meshheading:1356772-Coronary Artery Bypass,
pubmed-meshheading:1356772-Dopamine,
pubmed-meshheading:1356772-Dose-Response Relationship, Drug,
pubmed-meshheading:1356772-Drug Administration Schedule,
pubmed-meshheading:1356772-Female,
pubmed-meshheading:1356772-Heart Failure,
pubmed-meshheading:1356772-Heart Valve Prosthesis,
pubmed-meshheading:1356772-Hemodynamics,
pubmed-meshheading:1356772-Humans,
pubmed-meshheading:1356772-Infusions, Intravenous,
pubmed-meshheading:1356772-Male,
pubmed-meshheading:1356772-Middle Aged,
pubmed-meshheading:1356772-Mitral Valve,
pubmed-meshheading:1356772-Postoperative Complications
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Haemodynamic effects of different doses of dopexamine hydrochloride in low cardiac output states following cardiac surgery.
|
| pubmed:affiliation |
German Heart Institute Berlin.
|
| pubmed:publicationType |
Journal Article
|