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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1992-11-2
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pubmed:databankReference |
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pubmed:abstractText |
Hox-4.2 promoter activity was assayed by transient expression assays in P19 embryonal carcinoma (EC) cells. Cotransfection of a luciferase reporter gene construct driven by Hox-4.2 upstream sequences with an expression vector for the Hox-4.2 gene product resulted in a 20-fold increase in luciferase activity. This activity was specific in that the Hox-1.6 gene product had no effect in the same assay. Mutational analysis defined a cis-acting element with enhancer function which conferred most of this increase. Activation was largely dependent on two TAAT/ATTA motifs within this 217 bp fragment and HOX-4.2 bound specifically to both of these motifs. The 217 bp element maps within a highly conserved region of the human Hox-4.2 gene (HOX4B) which has been shown to display spatial enhancer activity in mice and flies. These findings suggest a conserved autoregulatory mechanism for the control of Hox-4.2 expression.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1356763-1346368,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1356763-3440520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1356763-3821727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1356763-4075400,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/1356763-6828386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1356763-7056443
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:geneSymbol |
HOX4B,
Hox-1.6,
Hox-4.2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3673-80
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
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