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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-10-22
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pubmed:abstractText |
The role of central versus peripheral influence of dopamine (DA) in the genesis of emotional stress (ES) induced by fear to receive electric footshocks on colonic motility was evaluated in rats equipped with implanted electrodes on the proximal colon. In control rats, the frequency of colonic spike bursts increased from 7.5 +/- 1.9 to 16.0 +/- 2.1 per 10 min when the rats were placed in a test box where they had previously received electric footshocks. This increase induced by ES was significantly p less than 0.05, reduced by previous ICV or IP administration of (+)SCH 23390 (a D1 receptor antagonist) at doses of 10 and 100 micrograms/Kg, respectively. Although sulpiride (a D2 antagonist) injected ICV or IP at similar doses had no effect on the ES-induced increase in the frequency of colonic spike bursts. DA (100 micrograms/kg), and the selective D1 (SKF 38383) or D2 (quinpirole) receptor agonist injected ICV at a dose of 5 micrograms/kg also increased significantly by 48.7, 54.8, and 68.7%, respectively, the colonic spike burst frequency whereas they are inactive when injected IP at similar and higher doses. These results suggest that, in rats, (a) emotional stress stimulates colonic motility through the stimulation of dopaminergic neurons involving D1 receptors and (b) exogenous activation of central D1 and D2 receptors similarly stimulate colonic motility by increasing the occurrence of colonic spike bursts.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-p...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Ergolines,
http://linkedlifedata.com/resource/pubmed/chemical/Quinpirole,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Sulpiride
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0361-9230
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-40
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1356067-2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine,
pubmed-meshheading:1356067-Animals,
pubmed-meshheading:1356067-Benzazepines,
pubmed-meshheading:1356067-Colon,
pubmed-meshheading:1356067-Dopamine,
pubmed-meshheading:1356067-Dopamine Agents,
pubmed-meshheading:1356067-Dopamine Antagonists,
pubmed-meshheading:1356067-Electrophysiology,
pubmed-meshheading:1356067-Emotions,
pubmed-meshheading:1356067-Ergolines,
pubmed-meshheading:1356067-Gastrointestinal Motility,
pubmed-meshheading:1356067-Injections, Intraperitoneal,
pubmed-meshheading:1356067-Injections, Intraventricular,
pubmed-meshheading:1356067-Male,
pubmed-meshheading:1356067-Quinpirole,
pubmed-meshheading:1356067-Rats,
pubmed-meshheading:1356067-Rats, Inbred Strains,
pubmed-meshheading:1356067-Receptors, Dopamine,
pubmed-meshheading:1356067-Receptors, Dopamine D1,
pubmed-meshheading:1356067-Receptors, Dopamine D2,
pubmed-meshheading:1356067-Stress, Psychological,
pubmed-meshheading:1356067-Sulpiride
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pubmed:year |
1992
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pubmed:articleTitle |
Involvement of central dopamine and D1 receptors in stress-induced colonic motor alterations in rats.
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pubmed:affiliation |
Department of Pharmacology, INRA, Toulouse, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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