| pubmed-article:1355662 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1355662 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:1355662 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:1355662 | lifeskim:mentions | umls-concept:C0034802 | lld:lifeskim |
| pubmed-article:1355662 | lifeskim:mentions | umls-concept:C0678222 | lld:lifeskim |
| pubmed-article:1355662 | lifeskim:mentions | umls-concept:C0069515 | lld:lifeskim |
| pubmed-article:1355662 | lifeskim:mentions | umls-concept:C0034804 | lld:lifeskim |
| pubmed-article:1355662 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:1355662 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:1355662 | lifeskim:mentions | umls-concept:C0080055 | lld:lifeskim |
| pubmed-article:1355662 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:1355662 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:1355662 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:1355662 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1355662 | pubmed:dateCreated | 1992-10-15 | lld:pubmed |
| pubmed-article:1355662 | pubmed:abstractText | The expression of p53 protein, oestrogen receptor protein, epidermal growth factor receptor (EGFR) and overexpression of the c-erbB-2 oncoprotein was examined in a series of 149 primary symptomatic breast carcinomas. Expression of p53 was present in 62 of 146 cases (42.5%) of the invasive carcinoma and one of three cases (33.3%) of ductal carcinoma in situ (DCIS) examined. Statistical associations of tumour oestrogen receptor positivity and lack of p53 protein expression, chi 2 = 19.78 (d.f. = 1), P less than 0.001, positive tumour p53 status and poor tumour grade; chi 2 = 14.1 (d.f. = 2), P less than 0.001, EGFR expression chi 2 = 7.07, (d.f. = 1), P less than 0.01 and tumour c-erbB-2 protein overexpression; chi 2 = 4.61 (d.f. = 1), P = 0.032 were identified. Expression of p53 is rare in invasive lobular carcinoma of classical type (8.3% of cases examined) in contrast to other common types of mammary carcinoma. Non-significant trends of p53 protein expression and increased regional tumour recurrence; chi 2 = 3.20 (d.f. = 1), P = 0.074 and also poorer patient survival; chi 2 = 3.76 (d.f. = 1), P = 0.053 were identified. p53 protein expression is a common event in human breast cancer and is present in both DCIS and invasive mammary carcinoma. Abnormal expression of p53 protein is a feature of both in situ and invasive breast carcinoma, implying that the abnormal p53 protein expression may be implicated in the early stages of mammary carcinoma progression. | lld:pubmed |
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| pubmed-article:1355662 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1355662 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1355662 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1355662 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1355662 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:1355662 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:1355662 | pubmed:author | pubmed-author:BellJ AJA | lld:pubmed |
| pubmed-article:1355662 | pubmed:author | pubmed-author:BlameyR WRW | lld:pubmed |
| pubmed-article:1355662 | pubmed:author | pubmed-author:ElstonC WCW | lld:pubmed |
| pubmed-article:1355662 | pubmed:author | pubmed-author:NicholsonR... | lld:pubmed |
| pubmed-article:1355662 | pubmed:author | pubmed-author:EllisI OIO | lld:pubmed |
| pubmed-article:1355662 | pubmed:author | pubmed-author:GaleaMM | lld:pubmed |
| pubmed-article:1355662 | pubmed:author | pubmed-author:PollerD NDN | lld:pubmed |
| pubmed-article:1355662 | pubmed:author | pubmed-author:HutchingsC... | lld:pubmed |
| pubmed-article:1355662 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1355662 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:1355662 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1355662 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1355662 | pubmed:pagination | 583-8 | lld:pubmed |
| pubmed-article:1355662 | pubmed:dateRevised | 2010-9-7 | lld:pubmed |
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| pubmed-article:1355662 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1355662 | pubmed:articleTitle | p53 protein expression in human breast carcinoma: relationship to expression of epidermal growth factor receptor, c-erbB-2 protein overexpression, and oestrogen receptor. | lld:pubmed |
| pubmed-article:1355662 | pubmed:affiliation | Department of Histopathology, City Hospital, Nottingham, UK. | lld:pubmed |
| pubmed-article:1355662 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1355662 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
