Linked Life Data

1355564

Source:http://linkedlifedata.com/resource/pubmed/id/1355564

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1992-10-6
pubmed:abstractText
In the evaluation of treatment failure in Streptococcus pyogenes pharyngitis it is necessary to distinguish between persistence of the original streptococcus and acquisition of a new strain. We used the analysis of restriction fragment length polymorphism (RFLP) of total DNA and of ribosomal DNA (rDNA) regions (ribotypes) as epidemiological tools to compare 43 pre- and post-treatment S. pyogenes strains obtained from 20 patients. In 16 cases pre- and post-treatment strains gave indistinguishable RFLP patterns of total DNA, strongly suggesting relapse with the same strain. However, in four cases different patterns were obtained for the pre- and post-treatment isolates, indicating recurrence due to the acquisition of a new strain. Ribotyping did not improve discrimination among strains. Thus, analysis of DNA RFLP is a promising method for distinguishing recurrence from relapse in failures of pharyngitis treatment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-2615
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
162-4
pubmed:dateRevised
2008-8-19
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
DNA restriction fragment length polymorphism differentiates recurrence from relapse in treatment failures of Streptococcus pyogenes pharyngitis.
pubmed:affiliation
Laboratoire de Bactériologie, Hôpital Robert Debré, Paris, France.
pubmed:publicationType
Journal Article, Comparative Study