Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1992-10-2
pubmed:abstractText
This review considers the biology of the type 1 growth factor receptor family which is increasingly recognised as important in the control of normal cell proliferation and in the pathogenesis of human cancer. The family currently comprises three closely related members: the epidermal growth factor (EGF) receptor, c-erbB-2 and c-erbB-3, all of which show abnormalities of expression in various human tumours. The family of factors related to EGF has also expanded recently and now includes transforming growth factor alpha, heparin-binding EGF, amphiregulin, cripto and heregulin, as well as several other potential ligands for the c-erbB2-2 receptor. The involvement of these receptors and growth factors in human cancer has implications for the design of novel forms of therapy for cancer, and we review recent advances and future avenues for investigation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/GPI-Linked Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances, http://linkedlifedata.com/resource/pubmed/chemical/Heparin, http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides..., http://linkedlifedata.com/resource/pubmed/chemical/Ligands, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-2, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, erbB-3, http://linkedlifedata.com/resource/pubmed/chemical/TDGF1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor alpha, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological, http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins, http://linkedlifedata.com/resource/pubmed/chemical/amphiregulin, http://linkedlifedata.com/resource/pubmed/chemical/heparin-binding EGF-like growth...
pubmed:status
MEDLINE
pubmed:issn
0955-2235
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-24
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:1355372-Amino Acid Sequence, pubmed-meshheading:1355372-Animals, pubmed-meshheading:1355372-Base Sequence, pubmed-meshheading:1355372-Caenorhabditis, pubmed-meshheading:1355372-Consensus Sequence, pubmed-meshheading:1355372-Drosophila, pubmed-meshheading:1355372-Drosophila Proteins, pubmed-meshheading:1355372-Epidermal Growth Factor, pubmed-meshheading:1355372-GPI-Linked Proteins, pubmed-meshheading:1355372-Gene Expression Regulation, pubmed-meshheading:1355372-Gene Expression Regulation, Neoplastic, pubmed-meshheading:1355372-Glycoproteins, pubmed-meshheading:1355372-Growth Substances, pubmed-meshheading:1355372-Heparin, pubmed-meshheading:1355372-Humans, pubmed-meshheading:1355372-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:1355372-Ligands, pubmed-meshheading:1355372-Mammals, pubmed-meshheading:1355372-Membrane Glycoproteins, pubmed-meshheading:1355372-Molecular Sequence Data, pubmed-meshheading:1355372-Multigene Family, pubmed-meshheading:1355372-Neoplasm Proteins, pubmed-meshheading:1355372-Neoplasms, pubmed-meshheading:1355372-Proto-Oncogene Proteins, pubmed-meshheading:1355372-Proto-Oncogenes, pubmed-meshheading:1355372-Receptor, Epidermal Growth Factor, pubmed-meshheading:1355372-Receptor, erbB-2, pubmed-meshheading:1355372-Receptor, erbB-3, pubmed-meshheading:1355372-Signal Transduction, pubmed-meshheading:1355372-Transforming Growth Factor alpha, pubmed-meshheading:1355372-Tumor Markers, Biological, pubmed-meshheading:1355372-Viral Proteins
pubmed:year
1992
pubmed:articleTitle
The type 1 (EGFR-related) family of growth factor receptors and their ligands.
pubmed:affiliation
Royal Postgraduate Medical School, Hammersmith Hospital, London, U.K.
pubmed:publicationType
Journal Article, Comparative Study, Review