| pubmed-article:1353913 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1353913 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1353913 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:1353913 | lifeskim:mentions | umls-concept:C0522537 | lld:lifeskim |
| pubmed-article:1353913 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:1353913 | lifeskim:mentions | umls-concept:C1328709 | lld:lifeskim |
| pubmed-article:1353913 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:1353913 | pubmed:dateCreated | 1992-9-8 | lld:pubmed |
| pubmed-article:1353913 | pubmed:abstractText | Anti-CD2 monoclonal antibodies (mAb) were used to influence graft survival in two transplantation models. Xenogeneic rat islets were transplanted intraportally into mice. Anti-CD2 mAb prolonged xenograft survival and was synergistic with UVB irradiation in prolonging survival. Anti-CD2 mAb was also more potent than an anti-CD4 mAb in this model. Allogeneic cardiac grafts were transplanted across an entire H-2 difference and anti-CD2 mAb prolonged allograft survival in a dose-dependent fashion. Kinetic experiments revealed that anti-CD2 mAb was most potent when administered at the time of allografting. A delay in administration of mAb markedly reduced its immunosuppressive effects. Furthermore, additional doses of mAb given after the initial doses provided no increased immunosuppression and anti-CD2 mAbs did not delay rejection of second-set allografts. These findings support the notion that anti-CD2 mAbs interfere with afferent immunity and that CD2 is most important during the initial steps of an immune response. Investigation of the effect of anti-CD2 mAb on cellular immune functions demonstrated, in agreement with previous results, that it caused antigenic down-modulation of CD2 with relative sparing of CD3, CD4, and CD8 cell surface expression. Concomitantly the MLR, CTL, and NK responses were suppressed. | lld:pubmed |
| pubmed-article:1353913 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1353913 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1353913 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1353913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1353913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1353913 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1353913 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1353913 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1353913 | pubmed:issn | 0041-1337 | lld:pubmed |
| pubmed-article:1353913 | pubmed:author | pubmed-author:BrombergJ SJS | lld:pubmed |
| pubmed-article:1353913 | pubmed:author | pubmed-author:ChavinK DKD | lld:pubmed |
| pubmed-article:1353913 | pubmed:author | pubmed-author:LauH THT | lld:pubmed |
| pubmed-article:1353913 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1353913 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:1353913 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1353913 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1353913 | pubmed:pagination | 286-91 | lld:pubmed |
| pubmed-article:1353913 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1353913 | pubmed:meshHeading | pubmed-meshheading:1353913-... | lld:pubmed |
| pubmed-article:1353913 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1353913 | pubmed:articleTitle | Prolongation of allograft and xenograft survival in mice by anti-CD2 monoclonal antibodies. | lld:pubmed |
| pubmed-article:1353913 | pubmed:affiliation | Department of Surgery, Medical University of South Carolina, Charleston 29425. | lld:pubmed |
| pubmed-article:1353913 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1353913 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1353913 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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