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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-9-3
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pubmed:abstractText |
1. Nicorandil, pinacidil and lemakalim relaxed precontracted rings of canine cerebral artery. 2. The order of potency was lemakalim greater than nicorandil approximately equal to pinacidil, but all these agents were less effective than nimodipine. 3. The effects of nicorandil were inhibited by methylene blue but not by glibenclamide, while the effects of pinacidil and lemakalim were inhibited by glibenclamide but not by methylene blue. 4. Thus nicorandil probably causes relaxation mostly by effects on guanylate cyclase while lemakalim and pinacidil produce the same effect by action at ATP-dependent potassium channels.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzopyrans,
http://linkedlifedata.com/resource/pubmed/chemical/Cromakalim,
http://linkedlifedata.com/resource/pubmed/chemical/Glyburide,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Methylene Blue,
http://linkedlifedata.com/resource/pubmed/chemical/Niacinamide,
http://linkedlifedata.com/resource/pubmed/chemical/Nicorandil,
http://linkedlifedata.com/resource/pubmed/chemical/Pinacidil,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0306-3623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
197-201
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pubmed:dateRevised |
2011-6-10
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pubmed:meshHeading |
pubmed-meshheading:1353469-Animals,
pubmed-meshheading:1353469-Basilar Artery,
pubmed-meshheading:1353469-Benzopyrans,
pubmed-meshheading:1353469-Cerebral Arteries,
pubmed-meshheading:1353469-Cromakalim,
pubmed-meshheading:1353469-Dogs,
pubmed-meshheading:1353469-Female,
pubmed-meshheading:1353469-Glyburide,
pubmed-meshheading:1353469-Guanidines,
pubmed-meshheading:1353469-Guanylate Cyclase,
pubmed-meshheading:1353469-Male,
pubmed-meshheading:1353469-Methylene Blue,
pubmed-meshheading:1353469-Muscle, Smooth, Vascular,
pubmed-meshheading:1353469-Muscle Contraction,
pubmed-meshheading:1353469-Niacinamide,
pubmed-meshheading:1353469-Nicorandil,
pubmed-meshheading:1353469-Pinacidil,
pubmed-meshheading:1353469-Potassium Channels,
pubmed-meshheading:1353469-Pyrroles,
pubmed-meshheading:1353469-Vasodilation,
pubmed-meshheading:1353469-Vasodilator Agents
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pubmed:year |
1992
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pubmed:articleTitle |
Vasodilatation of canine cerebral arteries by nicorandil, pinacidil and lemakalim.
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pubmed:affiliation |
Department of Surgery, University of Alberta, Edmonton, Canada.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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