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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1992-8-19
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pubmed:abstractText |
Scatchard analyses of [3H]prazosin binding in rat ventricular muscle membranes showed biphasic curves, which identified alpha 1High- and alpha 1Low-affinity sites. The alpha 1High-affinity site was completely inhibited by 1 microM phenoxybenzamine. The displacement potencies of alpha 1-adrenergic antagonists were characterized by [3H]prazosin binding to alpha 1High- and alpha 1Low-affinity sites in the absence and presence of 1 microM phenoxybenzamine. The affinities of most chemicals for alpha 1Low-affinity sites were significantly lower than those for alpha 1High-affinity sites, but WB-4101 (2-(2,6-dimethoxy-phenoxyethyl)aminomethyl-1,4-benzodioxane), arotinolol, cinanserin, nifedipine, and p-aminoclonidine had the same affinities for both alpha 1Low- and alpha 1High-affinity sites. These results show that two alpha 1-adrenoceptor subtypes, alpha 1High- and alpha 1Low-affinity, are present in the rat heart, and that there are physical variations in alpha 1-adrenoceptor binding sites, based on their selectivity to antagonists.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-3573
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-100
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1352824-Adrenergic alpha-Antagonists,
pubmed-meshheading:1352824-Animals,
pubmed-meshheading:1352824-Binding, Competitive,
pubmed-meshheading:1352824-Heart Ventricles,
pubmed-meshheading:1352824-Kinetics,
pubmed-meshheading:1352824-Male,
pubmed-meshheading:1352824-Myocardium,
pubmed-meshheading:1352824-Phenoxybenzamine,
pubmed-meshheading:1352824-Prazosin,
pubmed-meshheading:1352824-Rats,
pubmed-meshheading:1352824-Rats, Inbred Strains,
pubmed-meshheading:1352824-Receptors, Adrenergic, alpha,
pubmed-meshheading:1352824-Regression Analysis
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pubmed:year |
1992
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pubmed:articleTitle |
Alpha 1-adrenoceptor subtypes in the rat ventricular muscle.
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pubmed:affiliation |
Department of Pharmacology, Niigata College of Pharmacy, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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