Linked Life Data

13523126

Source:http://linkedlifedata.com/resource/pubmed/id/13523126

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1958-12-1
pubmed:abstractText
Sensitization to the cardio-accelerator action of adrenaline and noradrenaline by five antihistamines was examined on the acutely denervated heart of the cat. Antazoline (Antistin), chlorcyclizine and promethazine (Phenergan) increased the cardio-accelerator responses to both amines equally. Mepyramine (Anthisan) increased noradrenaline more than adrenaline action. Diphenhydramine (Benadryl) resembled cocaine in potentiating the responses to noradrenaline but not to adrenaline.On the nictitating membrane mepyramine caused sensitization to the actions of adrenaline, noradrenaline and tyramine, an effect similar to that of chronic preganglionic denervation. Diphenhydramine enhanced the action of noradrenaline more than that of adrenaline and had little effect on tyramine action, giving a sensitization which bears a greater resemblance to the type caused by cocaine or chronic postganglionic denervation.It is suggested that two distinct mechanisms are required to account for the phenomena of sensitization.
pubmed:commentsCorrections
pubmed:keyword
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
OM
pubmed:status
OLDMEDLINE
pubmed:month
Mar
pubmed:issn
0366-0826
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6-10
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1958
pubmed:articleTitle
Sensitization of the heart and nictitating membrane of the cat to sympathomimetic amines by antihistamine drugs.
pubmed:publicationType
Journal Article