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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1992-8-3
|
| pubmed:abstractText |
We analyzed the growth pattern of tumor masses and the survival of 39 asymptomatic Italian patients with a total of 59 small (less than or equal to 5 cm in diameter) hepatocellular carcinomas arising from cirrhosis. The total length of the observation period ranged from 90 to 962 days, with an average of 364 +/- 229 (mean +/- S.D.). Doubling time ranged from 27.2 to 605.6 days (mean +/- S.D., 204.2 +/- 135; median = 171.6 days). Three different growth patterns were recognized: (a) tumors with no or very slow initial growth pattern (doubling time greater than 200 days), 10 cases (37%); (b) tumors with declining growth rate over time, 9 cases (33.4%); and (c) tumors with almost constant growth rate, 8 cases (29.6%). Using the stepwise discriminant analysis, we found a score based on albumin, alcohol intake, number of nodules, echo pattern and histological type that allowed a correct prediction of short doubling time (less than or equal to 150 days) in 55.6%, medium doubling time (151 to 300 days) in 60% and long doubling time (greater than 300 days) in 100% of cases. The estimated survival rate of the 39 patients, calculated by the Kaplan-Meier method was 81% at 1 yr, 55.7% at 2 yr and 21% at 3 yr. Stepwise discriminant analysis showed that a score based on sex, HBsAg status, alcohol consumption, ascites, gamma-glutamyltranspeptidase, prothrombin time, Child-Pugh class and all the sonographical parameters could predict 2-yr survival in 100% of cases. We conclude that great variability of growth patterns exists among and within small hepatocellular carcinomas. Prediction of subsequent growth rate is unreliable in most cases.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0270-9139
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
132-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1352268-Alcohol Drinking,
pubmed-meshheading:1352268-Ascites,
pubmed-meshheading:1352268-Carcinoma, Hepatocellular,
pubmed-meshheading:1352268-Cell Division,
pubmed-meshheading:1352268-Female,
pubmed-meshheading:1352268-Follow-Up Studies,
pubmed-meshheading:1352268-Hepatitis B Surface Antigens,
pubmed-meshheading:1352268-Humans,
pubmed-meshheading:1352268-Liver Cirrhosis,
pubmed-meshheading:1352268-Liver Neoplasms,
pubmed-meshheading:1352268-Male,
pubmed-meshheading:1352268-Middle Aged,
pubmed-meshheading:1352268-Multivariate Analysis,
pubmed-meshheading:1352268-Prognosis,
pubmed-meshheading:1352268-Prothrombin Time,
pubmed-meshheading:1352268-Retrospective Studies,
pubmed-meshheading:1352268-Time Factors,
pubmed-meshheading:1352268-gamma-Glutamyltransferase
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Natural history of small untreated hepatocellular carcinoma in cirrhosis: a multivariate analysis of prognostic factors of tumor growth rate and patient survival.
|
| pubmed:affiliation |
Istituto di Clinica Medica e Gastroenterologia, University of Bologna, Italy.
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| pubmed:publicationType |
Journal Article
|