Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1992-7-10
pubmed:abstractText
Cells expressing human immunodeficiency virus type 1 (HIV-1) tat can transactivate the HIV-1 long terminal repeat (LTR) in cocultured T lymphocytes. In this report, we describe the molecular requirements for transcellular activation of the LTR in Jurkat cells. An analysis with deletion mutants and blocking antibodies demonstrated a requirement for env expression in addition to tat expression for transcellular activation to occur. The results suggest that the transient association of CD4 and gp120 in cocultured cells is required for tat-mediated transcellular activation. The events that follow CD4-gp120 binding in transactivation, however, do not require the gp120-neutralizing domain, in contrast to HIV-mediated fusion and infection. The consequences of this interaction on cellular function are currently under investigation.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-1602543, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-2418502, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-2420471, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-2431482, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-2452899, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-2556795, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-2849510, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-2957508, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-2990040, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-2990041, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-2994222, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-3001360, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-3014648, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-3016552, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-3094962, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-3095663, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-3201245, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-3477816, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-3530501, http://linkedlifedata.com/resource/pubmed/commentcorrection/1351104-3629244
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4536-9
pubmed:dateRevised
2010-9-7
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Transcellular activation of the human immunodeficiency virus type 1 long terminal repeat in T lymphocytes requires CD4-gp120 binding.
pubmed:affiliation
Department of Physiology and Cellular Biophysics, Columbia University, New York, New York 10032.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.