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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-7-7
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pubmed:abstractText |
The alpha 1-adrenoceptors of rat lung with a high affinity for [3H]-prazosin were subdivided into two populations (high and low affinity sites) by WB4101 and 5-methylurapidil but the proportions were different between both drugs. After pretreatment with chlorethylclonidine, WB4101 recognized only high affinity sites, while 5-methylurapidil still detected high and low affinity sites. These results indicate that alpha 1-adrenoceptors with a high affinity for WB4101 are not homogeneous in the rat lung, suggesting the possible existence of a new alpha 1-adrenoceptor subtype in addition to alpha 1A and alpha 1B subtypes.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6-7
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pubmed:dateRevised |
2010-9-7
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pubmed:meshHeading |
pubmed-meshheading:1350746-Adrenergic alpha-Antagonists,
pubmed-meshheading:1350746-Animals,
pubmed-meshheading:1350746-Binding, Competitive,
pubmed-meshheading:1350746-Dioxanes,
pubmed-meshheading:1350746-Lung,
pubmed-meshheading:1350746-Male,
pubmed-meshheading:1350746-Piperazines,
pubmed-meshheading:1350746-Prazosin,
pubmed-meshheading:1350746-Rats,
pubmed-meshheading:1350746-Rats, Inbred Strains,
pubmed-meshheading:1350746-Receptors, Adrenergic, alpha
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pubmed:year |
1992
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pubmed:articleTitle |
5-Methylurapidil may discriminate between alpha 1-adrenoceptors with a high affinity for WB4101 in rat lung.
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pubmed:affiliation |
Department of Second Surgery, Fukui Medical School, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro
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